You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SGCD
Delta-sarcoglycan

Protein Summary
Description
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337851
  • ENSP00000338343
  • ENSG00000170624
  • ENST00000435422
  • ENSP00000403003
  • ENST00000517913
  • ENSP00000429378

Symbol
  • SGD
  • DAGD
  • 35DAG
  • CMD1L
  • SGCDP
  • LGMDR6
  • SG-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein complex
0.91
co-expressed gene
0.85
disease perturbation
0.74
cell type or tissue
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.51   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.51   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
67
T-cell immunoglobulin and mucin domain 1 measurement
1
2
2
64.1
alcohol consumption measurement
3
1
3
64
metastatic colorectal cancer
1
2
0
6.5
58.4
disease progression measurement
1
2
0
6.5
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
67
T-cell immunoglobulin and mucin domain 1 measurement
2
64.1
alcohol consumption measurement
3
64
metastatic colorectal cancer
0
6.5
58.4
disease progression measurement
0
6.5
58.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan delta
VGNC:13586
462216
Macaque
sarcoglycan delta
715190
Mouse
MGI:1346525
24052
Rat
RGD:1306638
497892
Dog
sarcoglycan delta
VGNC:46093
612079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan delta
Macaque
sarcoglycan delta
Mouse
Rat
Dog
sarcoglycan delta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92629-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Dilated cardiomyopathy (DCM)
KEGG
Viral myocarditis
KEGG
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG
Hypertrophic cardiomyopathy (HCM)
Name
Explore in Pharos
Explore in Source
Dilated cardiomyopathy (DCM)
Viral myocarditis
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Hypertrophic cardiomyopathy (HCM)
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (93)
1 – 10 of 93
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.994409039
p_ni: 0.005567429
p_wrong: 0.000023533
Score: 0.209
Data Source: BioPlex,STRINGDB
DNAJB9
Tbio
Novelty: 0.00536296
p_int: 0.960361053
p_ni: 0.039638947
Score: 0.213
Data Source: BioPlex,STRINGDB
ACP2
Tbio
Family: Enzyme
Novelty: 0.00355652
p_int: 0.948863211
p_ni: 0.051131303
p_wrong: 0.000005486
Score: 0.176
Data Source: BioPlex,STRINGDB
FAM241B
Tdark
Novelty: 0.70797589
p_int: 0.841494735
p_ni: 0.158503766
p_wrong: 0.000001499
Score: 0.228
Data Source: BioPlex,STRINGDB
DMD
Tclin
Novelty: 0.00025661
Score: 0.986
Data Source: STRINGDB
SGCA
Tbio
Novelty: 0.00442268
Score: 0.985
Data Source: STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.973
Data Source: STRINGDB
SGCE
Tbio
Novelty: 0.00449577
Score: 0.967
Data Source: STRINGDB
SGCB
Tbio
Novelty: 0.00970061
Score: 0.963
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  186.51

PubMed score by year
PubTator Score  73.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: