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Tbio
PXDN
Peroxidasin homolog

Protein Summary
Description
Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252804
  • ENSP00000252804
  • ENSG00000130508

Symbol
  • KIAA0230
  • MG50
  • PRG2
  • VPO
  • VPO1
  • PXN
  • VPO
  • MG50
  • PRG2
  • ASGD7
  • COPOA
  • D2S448
  • D2S448E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.91
molecular function
0.88
PubMedID
0.88
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.95   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.95   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
1
1
0
3.5
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
0
3.5
1.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxidasin
VGNC:10745
458999
Mouse
MGI:1916925
69675
Rat
RGD:1560694
554172
Dog
peroxidasin
VGNC:45217
100687809
Horse
peroxidasin
VGNC:22055
100072948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxidasin
Mouse
Rat
Dog
peroxidasin
Horse
peroxidasin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92626-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Extracellular matrix organization
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
ERP44
Tbio
Novelty: 0.02352693
p_int: 0.999944194
p_ni: 0.000055804
p_wrong: 1e-9
Data Source: BioPlex
MATN2
Tbio
Novelty: 0.08506252
p_int: 0.999630058
p_ni: 0.000369942
Score: 0.238
Data Source: BioPlex,STRINGDB
NELL1
Tbio
Family: Enzyme
Novelty: 0.01325888
p_int: 0.999371785
p_ni: 0.000628215
Data Source: BioPlex
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.999203091
p_ni: 0.000796909
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.999043826
p_ni: 0.000956174
Data Source: BioPlex
CST8
Tbio
Novelty: 0.02316886
p_int: 0.998331613
p_ni: 0.001668387
Data Source: BioPlex
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.997455128
p_ni: 0.002544872
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.997288319
p_ni: 0.002711681
Score: 0.24
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.991533182
p_ni: 0.008466818
Data Source: BioPlex
NELL2
Tbio
Family: Enzyme
Novelty: 0.03760438
p_int: 0.990126441
p_ni: 0.009873559
Data Source: BioPlex
Publication Statistics
PubMed Score  123.95

PubMed score by year
PubTator Score  42.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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