Tbio NUP205 Nuclear pore complex protein Nup205

Protein Summary

Description

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q92621
• A6H8X3
• Q86YC1

Gene Name

• NUP205

Ensembl ID

• ENST00000285968
• ENSP00000285968
• ENSG00000155561

Symbol

• C7orf14
• KIAA0225
• NPHS13
• C7orf14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
pathway	0.99
virus perturbation	0.99
kinase perturbation	0.88
transcription factor binding site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0