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Tbio
DHX38
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Protein Summary
Description
Probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268482
  • ENSP00000268482
  • ENSG00000140829

Symbol
  • DDX38
  • KIAA0224
  • PRP16
  • RP84
  • DDX38
  • PRP16
  • PRPF16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
histone modification site profile
0.91
disease perturbation
0.79
co-expressed gene
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
1
2
77.4
HMG CoA reductase inhibitor use measurement
1
1
1
47.7
2
1
2
42.6
hematocrit
1
1
1
42.5
serum metabolite measurement
1
1
2
30.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
77.4
HMG CoA reductase inhibitor use measurement
1
47.7
2
42.6
hematocrit
1
42.5
serum metabolite measurement
2
30.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 38
VGNC:8977
454237
Macaque
DEAH-box helicase 38
709173
Mouse
MGI:1927617
64340
Rat
RGD:1310345
292007
Dog
DEAH-box helicase 38
VGNC:39948
479669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 38
Macaque
DEAH-box helicase 38
Mouse
Rat
Dog
DEAH-box helicase 38
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92620-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (339)
1 – 10 of 339
PPP4R2
Tbio
Family: Enzyme
Novelty: 0.15136638
p_int: 0.999987851
p_ni: 0.000012148
Score: 0.297
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999982848
p_ni: 0.000017152
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999242828
p_ni: 0.000757163
p_wrong: 9e-9
Data Source: BioPlex
SNRNP40
Tbio
Novelty: 0.16791896
p_int: 0.999118796
p_ni: 0.000881201
p_wrong: 3e-9
Score: 0.935
Data Source: BioPlex,STRINGDB
CD2BP2
Tbio
Novelty: 0.01440995
p_int: 0.995180796
p_ni: 0.004712839
p_wrong: 0.000106366
Score: 0.939
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.993609488
p_ni: 0.006390407
p_wrong: 1.05e-7
Data Source: BioPlex
AURKC
Tchem
Family: Kinase
Novelty: 0.00950433
p_int: 0.970154185
p_ni: 0.029737391
p_wrong: 0.000108424
Score: 0.163
Data Source: BioPlex,STRINGDB
CDKL5
Tchem
Family: Kinase
Novelty: 0.00444062
p_int: 0.968942447
p_ni: 0.030733296
p_wrong: 0.000324257
Score: 0.189
Data Source: BioPlex,STRINGDB
IFIT1B
Tdark
Novelty: 0.29249041
p_int: 0.954791433
p_ni: 0.041612552
p_wrong: 0.003596015
Score: 0.236
Data Source: BioPlex,STRINGDB
NEBL
Tbio
Novelty: 0.02155964
p_int: 0.953002458
p_ni: 0.037753168
p_wrong: 0.009244374
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  53.45

PubMed score by year
PubTator Score  18.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer