Tbio DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Protein Summary

Description

Probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92620
• B4DVG8
• D3DWS7
• O75212
• Q96HN7

Gene Name

• DHX38

Ensembl ID

• ENST00000268482
• ENSP00000268482
• ENSG00000140829

Symbol

• DDX38
• KIAA0224
• PRP16
• RP84
• DDX38
• PRP16
• PRPF16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.92
histone modification site profile	0.91
disease perturbation	0.79
co-expressed gene	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Pre-mrna-splicing Factor Atp-dependent Rna Helicase Prp16

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Pre-mrna-splicing Factor Atp-dependent Rna Helicase Prp16

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Pre-mrna-splicing Factor Atp-dependent Rna Helicase Prp16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.98   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.98   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0