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Tbio
ARHGAP45
Rho GTPase-activating protein 45

Protein Summary
Description
Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313093
  • ENSP00000316772
  • ENSG00000180448
  • ENST00000539243
  • ENSP00000439601

Symbol
  • HMHA1
  • KIAA0223
  • HA-1
  • HMHA1
  • HLA-HA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (170)
1 – 10 of 170
RAC1
Tbio
Family: Enzyme
Novelty: 0.00579565
Score: 0.968
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00039759
Score: 0.953
Data Source: STRINGDB
RHOBTB1
Tbio
Novelty: 0.04346745
Score: 0.951
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.0002729
Score: 0.947
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00123743
Score: 0.945
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.01298176
Score: 0.937
Data Source: STRINGDB
ACTR2
Tbio
Novelty: 0.01032806
Score: 0.931
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00407673
Score: 0.928
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.0076798
Score: 0.924
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.00359609
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.11

PubMed score by year
PubTator Score  620.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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