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Tbio
ZNF516
Zinc finger protein 516

Protein Summary
Description
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000443185
  • ENSP00000394757
  • ENSG00000101493

Symbol
  • KIAA0222
  • HsT287
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
virus perturbation
0.72
PubMedID
0.65
transcription factor
0.64
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999990413
p_ni:  0.000009587
Score:  0.515
Data Source:  BioPlex,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999990263
p_ni:  0.000009737
Score:  0.79
Data Source:  BioPlex,STRINGDB
LCOR
Tbio
Family:  TF
Novelty:  0.01638762
p_int:  0.999400793
p_ni:  0.000599207
Data Source:  BioPlex
ZBTB42
Tbio
Family:  TF
Novelty:  0.54038505
p_int:  0.976918077
p_ni:  0.023080592
p_wrong:  0.000001331
Score:  0.209
Data Source:  BioPlex,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.899
Data Source:  STRINGDB
PRDM16
Tbio
Family:  TF; Epigenetic
Novelty:  0.00261891
Score:  0.853
Data Source:  STRINGDB
CCDC78
Tbio
Novelty:  0.26467655
Score:  0.816
Data Source:  STRINGDB
CTBP2
Tchem
Novelty:  0.00538964
Score:  0.645
Data Source:  STRINGDB
KLF3
Tbio
Family:  TF
Novelty:  0.01470469
Score:  0.626
Data Source:  STRINGDB
NRIP1
Tbio
Novelty:  0.00551568
Score:  0.621
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
92.5
neutrophil count
2
2
2
85.3
monocyte count
1
1
1
70.9
myeloid white cell count
1
1
1
68.8
granulocyte percentage of myeloid white cells
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
92.5
neutrophil count
2
85.3
monocyte count
1
70.9
myeloid white cell count
1
68.8
granulocyte percentage of myeloid white cells
1
63.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 516
VGNC:7822
455480
Macaque
zinc finger protein 516
707509
Mouse
MGI:2443957
329003
Rat
RGD:1306817
291406
Dog
zinc finger protein 516
VGNC:48746
483930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 516
Macaque
zinc finger protein 516
Mouse
Rat
Dog
zinc finger protein 516
Publication Statistics
PubMed Score 4.67
PubMed score by year
PubTator Score 3.85
PubTator score by year