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Tbio
LARP4B
La-related protein 4B

Protein Summary
Description
Stimulates mRNA translation. This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316157
  • ENSP00000326128
  • ENSG00000107929
  • ENST00000612396
  • ENSP00000482767

Symbol
  • KIAA0217
  • LARP5
  • LARP5
  • KIAA0217
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.98
transcription factor perturbation
0.88
interacting protein
0.83
cellular component
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
3
8
10.1
96.9
basophil count
2
2
2
94.8
basophil percentage of leukocytes
2
2
2
94.6
eosinophil count
3
3
3
93.7
creatinine measurement
3
3
4
93.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
10.1
96.9
basophil count
2
94.8
basophil percentage of leukocytes
2
94.6
eosinophil count
3
93.7
creatinine measurement
4
93.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 4B
VGNC:5492
450259
Macaque
La ribonucleoprotein domain family member 4B
721993
Mouse
MGI:106330
217980
Rat
RGD:1310713
307070
Horse
La ribonucleoprotein domain family member 4B
VGNC:19588
100057616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 4B
Macaque
La ribonucleoprotein domain family member 4B
Mouse
Rat
Horse
La ribonucleoprotein domain family member 4B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92615-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (133)
1 – 10 of 133
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999997329
p_ni:  0.000002671
Data Source:  BioPlex
APOBEC3B
Tbio
Novelty:  0.008531
p_int:  0.999996725
p_ni:  4.46e-7
p_wrong:  0.000002829
Data Source:  BioPlex
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.99999407
p_ni:  0.00000593
Score:  0.15
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.99992475
p_ni:  0.00007525
Score:  0.19
Data Source:  BioPlex,STRINGDB
SCAF1
Tbio
Novelty:  0.08705338
p_int:  0.999914476
p_ni:  0.000085524
Data Source:  BioPlex
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999904431
p_ni:  0.000095569
Data Source:  BioPlex
APOBEC3F
Tbio
Novelty:  0.00603614
p_int:  0.999775512
p_ni:  0.000224457
p_wrong:  3e-8
Data Source:  BioPlex
YTHDC1
Tbio
Novelty:  0.0156474
p_int:  0.999771855
p_ni:  0.000228136
p_wrong:  9e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
PABPC4L
Tdark
Novelty:  0.94386609
p_int:  0.999639642
p_ni:  0.000350983
p_wrong:  0.000009375
Score:  0.352
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.999238999
p_ni:  0.000744255
p_wrong:  0.000016745
Data Source:  BioPlex
Publication Statistics
PubMed Score  10.76

PubMed score by year
PubTator Score  4.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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