Tbio MYO18A Unconventional myosin-XVIIIa

Protein Summary

Description

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q92614
• Q5H9U3
• Q5QD01
• Q5W9F9
• Q5W9G1
• Q8IXP8

Gene Name

• MYO18A

Ensembl ID

• ENST00000527372
• ENSP00000437073
• ENSG00000196535
• ENST00000531253
• ENSP00000434228
• ENST00000533112
• ENSP00000435932

Symbol

• CD245
• KIAA0216
• MYSPDZ
• MAJN
• MYSPDZ
• SPR210
• SP-R210

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.98
protein domain	0.92
transcription factor binding site profile	0.88
drug perturbation	0.87

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		52
tobacco smoke exposure measurement	EFO_0009115	1	1	1		20

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		52
tobacco smoke exposure measurement	EFO_0009115	1		20

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myosin XVIIIA	VGNC:12492	100615253
Macaque	myosin XVIIIA		711171
Mouse	myosin XVIIIA	MGI:2667185	360013
Rat	myosin XVIIIa	RGD:1562698	360570
Dog	myosin XVIIIA	VGNC:43557	480630

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myosin XVIIIA
Macaque	myosin XVIIIA
Mouse	myosin XVIIIA
Rat	myosin XVIIIa
Dog	myosin XVIIIA

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q92614-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)

Reactome (6)

PathwayCommons (1)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Reactome	Signaling by FGFR in disease	64 targets	R-HSA-1226099
Reactome	Signaling by FGFR1 in disease	39 targets	R-HSA-5655302

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Signaling by FGFR in disease	64 targets	R-HSA-1226099
Signaling by FGFR1 in disease	39 targets	R-HSA-5655302

Gene Ontology Terms (23)

Functions (5)

Components (7)

Processes (11)

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10

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GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB
ADP binding	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
DNA binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (113)

Explore Interacting Targets

1 – 10 of 113

• See Interactions on String-DB

MYL12B

Tbio

Novelty: 0.00999083

p_int: 0.999999914

p_ni: 8.6e-8

Score: 0.403

Data Source: BioPlex,STRINGDB

FAM9C

Tdark

Novelty: 0.86727989

p_int: 0.999998892

p_ni: 0.000001109

Data Source: BioPlex

MYL6

Tbio

Novelty: 0.00594485

p_int: 0.999996971

p_ni: 0.000003029

Score: 0.429

Data Source: BioPlex,STRINGDB

SLC30A6

Tbio

Family: Transporter

Novelty: 0.06083299

p_int: 0.998264614

p_ni: 0.001735386

Data Source: BioPlex

UPK3B

Tbio

Novelty: 0.12798085

p_int: 0.996482603

p_ni: 0.003517397

Score: 0.269

Data Source: BioPlex,STRINGDB

LIMS1

Tbio

Novelty: 0.00648304

p_int: 0.996282476

p_ni: 0.003717524

Score: 0.219

Data Source: BioPlex,STRINGDB

UQCRB

Tbio

Novelty: 0.02933046

p_int: 0.994147938

p_ni: 0.005852062

Score: 0.165

Data Source: BioPlex,STRINGDB

YEATS4

Tbio

Novelty: 0.02632024

p_int: 0.994021565

p_ni: 0.005978435

Data Source: BioPlex

MYL3

Tbio

Novelty: 0.00493817

p_int: 0.993892866

p_ni: 0.006107134

Score: 0.473

Data Source: BioPlex,STRINGDB

DDRGK1

Tbio

Novelty: 0.10774064

p_int: 0.991509018

p_ni: 0.008490982

Data Source: BioPlex

Publication Statistics

PubMed Score  19.68

PubMed score by year

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PubTator Score  20.45

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Golgi apparatus
Motor protein
Myosin
Nucleotide-binding

GWAS Trait Find Similar Targets

mathematical ability
tobacco smoke exposure measurement

MGI Phenotype Find Similar Targets

embryo phenotype
growth/size/body region phenotype
integument phenotype
limbs/digits/tail phenotype
liver/biliary system phenotype
mortality/aging
vision/eye phenotype