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Tbio
MYO18A
Unconventional myosin-XVIIIa

Protein Summary
Description
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveola ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000527372
  • ENSP00000437073
  • ENSG00000196535
  • ENST00000531253
  • ENSP00000434228
  • ENST00000533112
  • ENSP00000435932

Symbol
  • CD245
  • KIAA0216
  • MYSPDZ
  • MAJN
  • MYSPDZ
  • SPR210
  • SP-R210
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.98
protein domain
0.92
transcription factor binding site profile
0.88
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
52
tobacco smoke exposure measurement
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
52
tobacco smoke exposure measurement
1
20
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin XVIIIA
VGNC:12492
100615253
Macaque
myosin XVIIIA
711171
Mouse
MGI:2667185
360013
Rat
RGD:1562698
360570
Dog
myosin XVIIIA
VGNC:43557
480630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin XVIIIA
Macaque
myosin XVIIIA
Mouse
Rat
Dog
myosin XVIIIA
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92614-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Signaling by FGFR in disease
Reactome
Signaling by FGFR1 in disease
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Signaling by FGFR in disease
Signaling by FGFR1 in disease
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (113)
1 – 10 of 113
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.999999914
p_ni: 8.6e-8
Score: 0.403
Data Source: BioPlex,STRINGDB
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.999998892
p_ni: 0.000001109
Data Source: BioPlex
MYL6
Tbio
Novelty: 0.00594485
p_int: 0.999996971
p_ni: 0.000003029
Score: 0.429
Data Source: BioPlex,STRINGDB
SLC30A6
Tbio
Family: Transporter
Novelty: 0.06083299
p_int: 0.998264614
p_ni: 0.001735386
Data Source: BioPlex
UPK3B
Tbio
Novelty: 0.12798085
p_int: 0.996482603
p_ni: 0.003517397
Score: 0.269
Data Source: BioPlex,STRINGDB
LIMS1
Tbio
Novelty: 0.00648304
p_int: 0.996282476
p_ni: 0.003717524
Score: 0.219
Data Source: BioPlex,STRINGDB
UQCRB
Tbio
Novelty: 0.02933046
p_int: 0.994147938
p_ni: 0.005852062
Score: 0.165
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.994021565
p_ni: 0.005978435
Data Source: BioPlex
MYL3
Tbio
Novelty: 0.00493817
p_int: 0.993892866
p_ni: 0.006107134
Score: 0.473
Data Source: BioPlex,STRINGDB
DDRGK1
Tbio
Novelty: 0.10774064
p_int: 0.991509018
p_ni: 0.008490982
Data Source: BioPlex
Publication Statistics
PubMed Score  19.68

PubMed score by year
PubTator Score  20.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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