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Tbio
DOCK2
Dedicator of cytokinesis protein 2

Protein Summary
Description
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256935
  • ENSP00000256935
  • ENSG00000134516
  • ENST00000520908
  • ENSP00000429283

Symbol
  • KIAA0209
  • IMD40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
drug perturbation
0.87
biological process
0.79
interacting protein
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.76   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.76   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.8
66.4
prostate carcinoma
1
1
0
1.3
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.8
66.4
prostate carcinoma
0
1.3
18.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 2
VGNC:3969
471731
Macaque
dedicator of cytokinesis 2
704061
Mouse
MGI:2149010
94176
Dog
dedicator of cytokinesis 2
VGNC:40046
489128
Horse
dedicator of cytokinesis 2
VGNC:17265
100070446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 2
Macaque
dedicator of cytokinesis 2
Mouse
Dog
dedicator of cytokinesis 2
Horse
dedicator of cytokinesis 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92608-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HIV Infection
Reactome
Hemostasis
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Disease
Factors involved in megakaryocyte development and platelet production
HIV Infection
Hemostasis
Host Interactions of HIV factors
Protein-Protein Interactions (182)
1 – 10 of 182
ELMO1
Tbio
Novelty: 0.01598587
Score: 0.996
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.993
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.975
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.974
Data Source: Reactome,STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.97
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.968
Data Source: STRINGDB
FGR
Tchem
Family: Kinase
Novelty: 0.00262848
Score: 0.941
Data Source: STRINGDB
HCK
Tclin
Family: Kinase
Novelty: 0.00237485
Score: 0.938
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.924
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.76

PubMed score by year
PubTator Score  31.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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