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Tbio
CNOT9
CCR4-NOT transcription complex subunit 9

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273064
  • ENSP00000273064
  • ENSG00000144580
  • ENST00000295701
  • ENSP00000295701
  • ENST00000542068
  • ENSP00000443687
  • ENST00000627282
  • ENSP00000486540

Symbol
  • RCD1
  • RQCD1
  • RCD1
  • CAF40
  • CT129
  • RCD-1
  • RQCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999988377
p_ni:  0.000011623
Score:  0.872
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999983619
p_ni:  0.000016381
Score:  0.999
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999978319
p_ni:  0.000021681
Score:  0.964
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999969513
p_ni:  0.000030487
Score:  0.977
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999951449
p_ni:  0.000048551
Data Source:  BioPlex
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999930474
p_ni:  0.000069526
Score:  0.997
Data Source:  BioPlex,STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.999928171
p_ni:  0.000071829
Score:  0.656
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999872057
p_ni:  0.000127943
Score:  0.561
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999685769
p_ni:  0.000314231
Score:  0.999
Data Source:  BioPlex,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
p_int:  0.995564127
p_ni:  0.004435873
Score:  0.561
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
92.7
hematocrit
2
2
2
91.4
reticulocyte count
2
2
2
90.4
reticulocyte measurement
2
1
2
74.8
BMI-adjusted hip circumference
1
2
2
71.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
92.7
hematocrit
2
91.4
reticulocyte count
2
90.4
reticulocyte measurement
2
74.8
BMI-adjusted hip circumference
2
71.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 9
VGNC:10076
741696
Macaque
CCR4-NOT transcription complex subunit 9
701978
Mouse
MGI:1928902
58184
Rat
RGD:1311495
301513
Dog
CCR4-NOT transcription complex subunit 9
VGNC:39420
610449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 9
Macaque
CCR4-NOT transcription complex subunit 9
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 9
Publication Statistics
PubMed Score 19.05
PubMed score by year
PubTator Score 3.25
PubTator score by year
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Related Publications
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PMID
Year
Title