Tbio SEPT8 Septin-8

Protein Summary

Description

Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q92599
• A6NC65
• A6NKP6
• F6W7K9
• Q8IX36
• Q8IX37
• Q9BVB3

Gene Name

• SEPT8

Ensembl ID

• ENST00000296873
• ENSP00000296873
• ENSG00000164402
• ENST00000378699
• ENSP00000367971
• ENST00000378719
• ENSP00000367991
• ENST00000448933
• ENSP00000399840
• ENST00000458488
• ENSP00000394766

Symbol

• KIAA0202
• SEP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
transcription factor perturbation	0.74
histone modification site profile	0.69
cell line	0.66
interacting protein	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-8

Protein / Cytoskeletal Protein / Septin-8

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.9   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.9   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0