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Tbio
NDRG1
Protein NDRG1

Protein Summary
Description
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cau ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323851
  • ENSP00000319977
  • ENSG00000104419
  • ENST00000414097
  • ENSP00000404854
  • ENST00000522476
  • ENSP00000427894
  • ENST00000537882
  • ENSP00000437443

Symbol
  • CAP43
  • DRG1
  • RTP
  • GC4
  • RTP
  • DRG1
  • NDR1
  • NMSL
  • TDD5
  • CAP43
  • CMT4D
  • DRG-1
  • HMSNL
  • RIT42
  • TARG1
  • PROXY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
protein complex
1
transcription factor perturbation
1
gene perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.49   (req: < 5)
Gene RIFs: 165   (req: <= 3)
Antibodies: 582   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.49   (req: >= 5)
Gene RIFs: 165   (req: > 3)
Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
0
5.6
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
5.6
0.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-myc downstream regulated 1
VGNC:1165
464411
Macaque
N-myc downstream regulated 1
697752
Mouse
MGI:1341799
17988
Rat
RGD:1307303
299923
Dog
N-myc downstream regulated 1
482049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-myc downstream regulated 1
Macaque
N-myc downstream regulated 1
Mouse
Rat
Dog
N-myc downstream regulated 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
FXYD1
Tbio
Family: IC
Novelty: 0.00421639
p_int: 0.9999995
p_ni: 5e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999788319
p_ni: 0.000211383
p_wrong: 2.97e-7
Data Source: BioPlex
S1PR2
Tchem
Family: GPCR
Novelty: 0.00372765
p_int: 0.99973262
p_ni: 0.000267321
p_wrong: 5.9e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.998315756
p_ni: 0.000186394
p_wrong: 0.00149785
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.996435399
p_ni: 0.000522803
p_wrong: 0.003041798
Data Source: BioPlex
NDRG2
Tbio
Novelty: 0.01061428
p_int: 0.910868455
p_ni: 0.004455789
p_wrong: 0.084675755
Score: 0.874
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.945
Data Source: STRINGDB
MYCN
Tbio
Family: TF
Novelty: 0.00038165
Score: 0.919
Data Source: STRINGDB
SGK1
Tchem
Family: Kinase
Novelty: 0.00155681
Score: 0.908
Data Source: STRINGDB
STK38L
Tchem
Family: Kinase
Novelty: 0.05193219
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  326.49

PubMed score by year
PubTator Score  268.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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