Tbio MAML1 Mastermind-like protein 1

Protein Summary

Description

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92585
• Q9NZ12
• Mam-1

Gene Name

• MAML1

Ensembl ID

• ENST00000292599
• ENSP00000292599
• ENSG00000161021
• ENST00000638220
• ENSP00000491444
• ENSG00000283780

Symbol

• KIAA0200
• Mam1
• Mam-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
biological process	0.76
transcription factor binding site profile	0.76
histone modification site profile	0.69
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mastermind-like Protein 1

DTO Classes

Protein / Transcription Factor / Mastermind-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.7   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.7   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0