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Tbio
MAML1
Mastermind-like protein 1

Protein Summary
Description
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292599
  • ENSP00000292599
  • ENSG00000161021
  • ENST00000638220
  • ENSP00000491444
  • ENSG00000283780

Symbol
  • KIAA0200
  • Mam1
  • Mam-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
biological process
0.76
transcription factor binding site profile
0.76
histone modification site profile
0.69
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.48   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.48   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
4
87.5
neutrophil count
3
4
4
87.5
monocyte percentage of leukocytes
2
2
2
82.3
monocyte percentage of leukocytes
2
2
2
82.3
myeloid white cell count
2
2
2
81.8
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
87.5
neutrophil count
4
87.5
monocyte percentage of leukocytes
2
82.3
monocyte percentage of leukocytes
2
82.3
myeloid white cell count
2
81.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mastermind like transcriptional coactivator 1
VGNC:13543
471772
Macaque
mastermind like transcriptional coactivator 1
715047
Mouse
MGI:1890504
103806
Rat
RGD:1308631
303101
Dog
mastermind like transcriptional coactivator 1
VGNC:42939
481457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mastermind like transcriptional coactivator 1
Macaque
mastermind like transcriptional coactivator 1
Mouse
Rat
Dog
mastermind like transcriptional coactivator 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92585-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Protein-Protein Interactions (110)
1 – 10 of 110
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.999999995
p_ni:  5e-9
Data Source:  BioPlex
MAML3
Tbio
Novelty:  0.05574812
Score:  0.999
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.999
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.999
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.992
Data Source:  Reactome,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.991
Data Source:  Reactome,STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.978
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.969
Data Source:  Reactome,STRINGDB
CDK8
Tchem
Family:  Kinase
Novelty:  0.00508026
Score:  0.955
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  72.48

PubMed score by year
PubTator Score  43.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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