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Tbio
CCL17
C-C motif chemokine 17

Protein Summary
Description
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219244
  • ENSP00000219244
  • ENSG00000102970
  • ENST00000616880
  • ENSP00000480147

Symbol
  • SCYA17
  • TARC
  • TARC
  • ABCD-2
  • SCYA17
  • A-152E5.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.8
PubMedID
0.78
cell type or tissue
0.65
chemical
0.57
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.03   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 475   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.03   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 475   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
1
1
86.9
CCL17 measurement
1
1
1
79.4
blood protein measurement
1
1
1
76.7
high density lipoprotein cholesterol measurement
1
1
1
64
hematocrit
2
2
2
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
86.9
CCL17 measurement
1
79.4
blood protein measurement
1
76.7
high density lipoprotein cholesterol measurement
1
64
hematocrit
2
62.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 17
574180
Mouse
MGI:1329039
20295
Rat
RGD:619924
117518
Dog
C-C motif chemokine ligand 17
VGNC:38882
403586
Horse
C-C motif chemokine ligand 17
VGNC:51150
100630824
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 17
Mouse
Rat
Dog
C-C motif chemokine ligand 17
Horse
C-C motif chemokine ligand 17
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92583-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Dectin-1 mediated noncanonical NF-kB signaling
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Dectin-1 mediated noncanonical NF-kB signaling
Immune System
Innate Immune System
Protein-Protein Interactions (131)
1 – 10 of 131
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.981150341
p_ni:  0.018849647
p_wrong:  1.1e-8
Data Source:  BioPlex
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.944145423
p_ni:  0.055853523
p_wrong:  0.000001054
Data Source:  BioPlex
HLA-DQA1
Tbio
Novelty:  0.00077488
p_int:  0.898343716
p_ni:  0.000152301
p_wrong:  0.101503983
Data Source:  BioPlex
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.887894834
p_ni:  0.112105166
Data Source:  BioPlex
ADAM17
Tchem
Family:  Enzyme
Novelty:  0.00121971
p_int:  0.759441904
p_ni:  0.240558096
Score:  0.19
Data Source:  BioPlex,STRINGDB
CCR4
Tclin
Family:  GPCR
Novelty:  0.01074935
Score:  0.977
Data Source:  STRINGDB
TSLP
Tbio
Novelty:  0.00140333
Score:  0.938
Data Source:  STRINGDB
CCR8
Tchem
Family:  GPCR
Novelty:  0.00525007
Score:  0.916
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.9
Data Source:  STRINGDB
CCR7
Tchem
Family:  GPCR
Novelty:  0.00084453
Score:  0.873
Data Source:  STRINGDB
Publication Statistics
PubMed Score  701.03

PubMed score by year
PubTator Score  302.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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