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Tbio
TSC1
Hamartin

Protein Summary
Description
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298552
  • ENSP00000298552
  • ENSG00000165699
  • ENST00000440111
  • ENSP00000394524
  • ENST00000545250
  • ENSP00000444017
  • ENST00000643072
  • ENSP00000496691
  • ENST00000643875
  • ENSP00000495158
  • ENST00000646625
  • ENSP00000496263

Symbol
  • KIAA0243
  • TSC
  • LAM
  • TSC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.93
hub protein
0.92
histone modification site profile
0.85
kinase perturbation
0.84


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.98   (req: < 5)
Gene RIFs: 156   (req: <= 3)
Antibodies: 1764   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.98   (req: >= 5)
Gene RIFs: 156   (req: > 3)
Antibodies: 1764   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TSC complex subunit 1
VGNC:48987
464818
Macaque
TSC complex subunit 1
714645
Mouse
MGI:1929183
64930
Rat
RGD:620124
60445
Dog
TSC complex subunit 1
VGNC:47890
480688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TSC complex subunit 1
Macaque
TSC complex subunit 1
Mouse
Rat
Dog
TSC complex subunit 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (52)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (61)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (163)
1 – 10 of 163
TBC1D7
Tbio
Novelty: 0.06502242
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AKTIP
Tbio
Novelty: 0.00315951
p_int: 0.999867388
p_ni: 0.000132588
p_wrong: 2.4e-8
Score: 0.336
Data Source: BioPlex,STRINGDB
TSC2
Tbio
Novelty: 0.00067416
Score: 0.999
Data Source: Reactome,STRINGDB
RHEB
Tbio
Family: Enzyme
Novelty: 0.00313935
Score: 0.998
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.988
Data Source: STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
Score: 0.987
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.984
Data Source: STRINGDB
RICTOR
Tbio
Novelty: 0.00250734
Score: 0.98
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.975
Data Source: STRINGDB
RRAGA
Tbio
Novelty: 0.02022668
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  225.98

PubMed score by year
PubTator Score  929.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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