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Tbio
NR4A3
Nuclear receptor subfamily 4 group A member 3

Protein Summary
Description
Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330847
  • ENSP00000333122
  • ENSG00000119508
  • ENST00000338488
  • ENSP00000340301
  • ENST00000395097
  • ENSP00000378531
  • ENST00000618101
  • ENSP00000482027

Symbol
  • CHN
  • CSMF
  • MINOR
  • NOR1
  • TEC
  • CHN
  • TEC
  • CSMF
  • NOR1
  • MINOR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor binding site profile
0.93
protein domain
0.92
molecular function
0.88
PubMedID
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.8   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.8   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (48)
1 – 10 of 48
RUNX1
Tbio
Family: TF
Novelty: 0.00847283
Score: 0.902
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.08455808
Score: 0.9
Data Source: STRINGDB
STX17
Tbio
Novelty: 0.02766436
Score: 0.756
Data Source: STRINGDB
TAF15
Tbio
Novelty: 0.06055363
Score: 0.753
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00299273
Score: 0.739
Data Source: STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00546341
Score: 0.711
Data Source: STRINGDB
TFG
Tbio
Novelty: 0.00472184
Score: 0.71
Data Source: STRINGDB
EWSR1
Tbio
Novelty: 0.00082042
Score: 0.641
Data Source: STRINGDB
FUS
Tbio
Novelty: 0.000554
Score: 0.64
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00267713
Score: 0.609
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.80

PubMed score by year
PubTator Score  241.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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