You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NR4A3
Nuclear receptor subfamily 4 group A member 3

Protein Summary
Description
Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330847
  • ENSP00000333122
  • ENSG00000119508
  • ENST00000338488
  • ENSP00000340301
  • ENST00000395097
  • ENSP00000378531
  • ENST00000618101
  • ENSP00000482027

Symbol
  • CHN
  • CSMF
  • MINOR
  • NOR1
  • TEC
  • CHN
  • TEC
  • CSMF
  • NOR1
  • MINOR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor binding site profile
0.93
protein domain
0.92
molecular function
0.88
PubMedID
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.12   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.12   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
17.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 3
VGNC:4809
464615
Macaque
nuclear receptor subfamily 4 group A member 3
717560
Mouse
MGI:1352457
18124
Rat
RGD:61882
58853
Horse
nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 3
Macaque
nuclear receptor subfamily 4 group A member 3
Mouse
Rat
Horse
nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92570-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (48)
1 – 10 of 48
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.902
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.9
Data Source: STRINGDB
STX17
Tbio
Novelty: 0.01788363
Score: 0.756
Data Source: STRINGDB
TAF15
Tbio
Novelty: 0.0621505
Score: 0.753
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00599946
Score: 0.739
Data Source: STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
Score: 0.711
Data Source: STRINGDB
TFG
Tbio
Novelty: 0.00320616
Score: 0.71
Data Source: STRINGDB
EWSR1
Tbio
Novelty: 0.00068411
Score: 0.641
Data Source: STRINGDB
FUS
Tbio
Novelty: 0.00065625
Score: 0.64
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.609
Data Source: STRINGDB
Publication Statistics
PubMed Score  133.12

PubMed score by year
PubTator Score  241.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: