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Tbio
PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma

Protein Summary
Description
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262741
  • ENSP00000262741
  • ENSG00000117461
  • ENST00000372006
  • ENSP00000361075
  • ENST00000420542
  • ENSP00000412546
  • ENST00000423209
  • ENSP00000391431

Symbol
  • p55
  • p55PIK
  • p55-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
gene perturbation
0.94
hub protein
0.92
pathway
0.91
PubMedID
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.28   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.28   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
2
88.2
hematocrit
1
1
1
82
hemoglobin measurement
1
1
1
80.6
myeloid white cell count
1
1
1
77.7
neutrophil count
1
1
1
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
88.2
hematocrit
1
82
hemoglobin measurement
1
80.6
myeloid white cell count
1
77.7
neutrophil count
1
76.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109277
18710
Rat
RGD:621042
60664
Dog
phosphoinositide-3-kinase regulatory subunit 3
100856339
Cow
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
286865
Anole lizard
phosphoinositide-3-kinase regulatory subunit 3
100554618
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphoinositide-3-kinase regulatory subunit 3
Cow
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Anole lizard
phosphoinositide-3-kinase regulatory subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (176)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Protein-Protein Interactions (392)
1 – 10 of 392
IRS2
Tbio
Novelty:  0.00164304
p_int:  1
Score:  0.972
Data Source:  BioPlex,STRINGDB
PIK3CD
Tclin
Family:  Kinase
Novelty:  0.00572779
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.999991998
p_ni:  0.000008002
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
p_int:  0.999974586
p_ni:  0.000025414
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
EHD2
Tbio
Novelty:  0.02724854
p_int:  0.997509337
p_ni:  0.002490659
p_wrong:  4e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
p_int:  0.990984064
p_ni:  0.009015936
Score:  0.982
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.958674123
p_ni:  0.041325877
Score:  0.361
Data Source:  BioPlex,STRINGDB
NISCH
Tclin
Novelty:  0.00137246
p_int:  0.954706713
p_ni:  0.045293285
p_wrong:  2e-9
Score:  0.6
Data Source:  BioPlex,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
p_int:  0.94430652
p_ni:  0.05569348
Score:  0.982
Data Source:  BioPlex,STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.890413319
p_ni:  0.109586681
Data Source:  BioPlex
Publication Statistics
PubMed Score  74.28

PubMed score by year
PubTator Score  51.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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