You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPOCK2
Testican-2

Protein Summary
Description
May participate in diverse steps of neurogenesis. Binds calcium. This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317376
  • ENSP00000321108
  • ENSG00000107742
  • ENST00000373109
  • ENSP00000362201
  • ENST00000412663
  • ENSP00000397715

Symbol
  • KIAA0275
  • TICN2
  • testican-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.83
PubMedID
0.79
gene perturbation
0.74
small molecule perturbation
0.67
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
14.2
1
1
0
1.2
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
14.2
0
1.2
1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
VGNC:14342
450518
Macaque
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
708963
Mouse
MGI:1891351
94214
Rat
RGD:1308568
361840
Dog
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
VGNC:46751
489037
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Macaque
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
Mouse
Rat
Dog
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92563-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (20)
1 – 10 of 20
MMP16
Tchem
Family:  Enzyme
Novelty:  0.01028533
Score:  0.716
Data Source:  STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.683
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.649
Data Source:  STRINGDB
FST
Tbio
Novelty:  0.00085875
Score:  0.643
Data Source:  STRINGDB
SPARCL1
Tbio
Novelty:  0.01077806
Score:  0.602
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.571
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.543
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.541
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.539
Data Source:  STRINGDB
DMTF1
Tbio
Family:  TF
Novelty:  0.06368405
Score:  0.472
Data Source:  STRINGDB
Publication Statistics
PubMed Score  22.26

PubMed score by year
PubTator Score  7.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer