Tbio WASF1 Wiskott-Aldrich syndrome protein family member 1

Protein Summary

Description

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92558
• E1P5F2
• Q5SZK7
• WASP family protein member 1

Gene Name

• WASF1

Ensembl ID

• ENST00000359451
• ENSP00000352425
• ENSG00000112290
• ENST00000392586
• ENSP00000376365
• ENST00000392587
• ENSP00000376366
• ENST00000392588
• ENSP00000376367
• ENST00000392589
• ENSP00000376368

Symbol

• KIAA0269
• SCAR1
• WAVE1
• WAVE
• SCAR1
• WAVE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.85
transcription factor binding site profile	0.8
tissue sample	0.72
histone modification site profile	0.7
interacting protein	0.62

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.57   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.57   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0