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Tbio
WASF1
Wiskott-Aldrich syndrome protein family member 1

Protein Summary
Description
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359451
  • ENSP00000352425
  • ENSG00000112290
  • ENST00000392586
  • ENSP00000376365
  • ENST00000392587
  • ENSP00000376366
  • ENST00000392588
  • ENSP00000376367
  • ENST00000392589
  • ENSP00000376368

Symbol
  • KIAA0269
  • SCAR1
  • WAVE1
  • WAVE
  • SCAR1
  • WAVE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
transcription factor binding site profile
0.8
tissue sample
0.72
histone modification site profile
0.7
interacting protein
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.44   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.44   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (23)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (166)
1 – 10 of 166
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.999999992
p_ni: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999999991
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999999989
p_ni: 1e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999833
p_ni: 1.67e-7
Score: 0.616
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999996949
p_ni: 0.00000305
Score: 0.243
Data Source: BioPlex,STRINGDB
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999988246
p_ni: 0.000011754
Score: 0.666
Data Source: BioPlex,STRINGDB
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.12113722
p_int: 0.999966676
p_ni: 0.000033324
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999774677
p_ni: 0.000225323
Score: 0.518
Data Source: BioPlex,STRINGDB
CBLC
Tbio
Family: Enzyme
Novelty: 0.14017765
p_int: 0.999743656
p_ni: 0.000256343
Score: 0.641
Data Source: BioPlex,STRINGDB
NHSL2
Tdark
Novelty: 4.36275023
p_int: 0.999705866
p_ni: 0.00029304
p_wrong: 0.000001094
Score: 0.663
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  107.44

PubMed score by year
PubTator Score  891.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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