Tbio ELMO1 Engulfment and cell motility protein 1

Protein Summary

Description

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q92556
• A4D1X6
• Q29R79
• Q6ZTJ0
• Q96PB0
• Q9H0I1

Gene Name

• ELMO1

Ensembl ID

• ENST00000310758
• ENSP00000312185
• ENSG00000155849
• ENST00000396040
• ENSP00000379355
• ENST00000396045
• ENSP00000379360
• ENST00000442504
• ENSP00000406952
• ENST00000448602
• ENSP00000394458

Symbol

• KIAA0281
• CED12
• CED-12
• ELMO-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
protein domain	0.85
PubMedID	0.81
microRNA	0.8
transcription factor binding site profile	0.8

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Engulfment And Cell Motility Protein 1

DTO Classes

Protein / Signaling / Engulfment And Cell Motility Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.35   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.35   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0