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Tbio
ELMO1
Engulfment and cell motility protein 1

Protein Classes
Protein Summary
Description
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310758
  • ENSP00000312185
  • ENSG00000155849
  • ENST00000396040
  • ENSP00000379355
  • ENST00000396045
  • ENSP00000379360
  • ENST00000442504
  • ENSP00000406952
  • ENST00000448602
  • ENSP00000394458

Symbol
  • KIAA0281
  • CED12
  • CED-12
  • ELMO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.85
PubMedID
0.81
microRNA
0.8
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.16   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.16   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
95.1
eosinophil count
3
2
3
91.6
eosinophil percentage of leukocytes
2
1
2
78.6
lymphocyte count
2
1
2
73
2
1
0
1.1
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
95.1
eosinophil count
3
91.6
eosinophil percentage of leukocytes
2
78.6
lymphocyte count
2
73
0
1.1
71.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 1
VGNC:4337
463354
Macaque
engulfment and cell motility 1
705818
Mouse
MGI:2153044
140580
Rat
RGD:1308182
361251
Dog
engulfment and cell motility 1
VGNC:40309
612913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 1
Macaque
engulfment and cell motility 1
Mouse
Rat
Dog
engulfment and cell motility 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92556-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (52)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Disease
Fcgamma receptor (FCGR) dependent phagocytosis
HIV Infection
Host Interactions of HIV factors
Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (141)
1 – 10 of 141
DOCK5
Tbio
Novelty:  0.03153692
p_int:  1
Score:  0.892
Data Source:  BioPlex,STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DOCK4
Tbio
Novelty:  0.02356655
p_int:  0.999999979
p_ni:  2.2e-8
Score:  0.93
Data Source:  BioPlex,STRINGDB
DOCK3
Tbio
Novelty:  0.02190804
p_int:  0.999999971
p_ni:  1e-9
p_wrong:  2.8e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.99999984
p_ni:  1.6e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
p_int:  0.999999531
p_ni:  4.65e-7
p_wrong:  3e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999993493
p_ni:  0.000006506
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
MED31
Tbio
Family:  Enzyme
Novelty:  0.05516854
p_int:  0.999988209
p_ni:  0.000010542
p_wrong:  0.000001249
Score:  0.299
Data Source:  BioPlex,STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
p_int:  0.999817365
p_ni:  0.000177526
p_wrong:  0.000005109
Score:  0.986
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.972881976
p_ni:  0.025681061
p_wrong:  0.001436963
Data Source:  BioPlex
Publication Statistics
PubMed Score  80.16

PubMed score by year
PubTator Score  38.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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