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Tbio
TOPBP1
DNA topoisomerase 2-binding protein 1

Protein Summary
Description
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260810
  • ENSP00000260810
  • ENSG00000163781

Symbol
  • KIAA0259
  • Dpb11
  • TOP2BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
cellular component
0.74
transcription factor binding site profile
0.73
kinase perturbation
0.66
virus
0.66


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.14   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.14   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase II binding protein 1
VGNC:8849
460709
Macaque
DNA topoisomerase II binding protein 1
719054
Mouse
MGI:1920018
235559
Rat
RGD:1562949
315969
Dog
DNA topoisomerase II binding protein 1
VGNC:49635
477070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase II binding protein 1
Macaque
DNA topoisomerase II binding protein 1
Mouse
Rat
Dog
DNA topoisomerase II binding protein 1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (221)
1 – 10 of 221
CBLN4
Tbio
Novelty: 0.11296355
p_int: 1
Score: 0.206
Data Source: BioPlex,STRINGDB
PHF8
Tchem
Family: Epigenetic
Novelty: 0.01946151
p_int: 0.999999755
p_ni: 9.8e-8
p_wrong: 1.47e-7
Data Source: BioPlex
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
p_int: 0.999995869
p_ni: 0.000004115
p_wrong: 1.6e-8
Score: 0.724
Data Source: BioPlex,STRINGDB
CDO1
Tbio
Family: Enzyme
Novelty: 0.01682989
p_int: 0.93514179
p_ni: 0.000039136
p_wrong: 0.064819074
Score: 0.29
Data Source: BioPlex,STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
Score: 0.997
Data Source: STRINGDB
RAD9A
Tbio
Novelty: 0.00560195
Score: 0.997
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.996
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.996
Data Source: STRINGDB
ATRIP
Tbio
Novelty: 0.01415267
Score: 0.995
Data Source: STRINGDB
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  143.14

PubMed score by year
PubTator Score  95.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer