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Tbio
TM9SF4
Transmembrane 9 superfamily member 4

Protein Classes
Protein Summary
Description
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398022
  • ENSP00000381104
  • ENSG00000101337

Symbol
  • KIAA0255
  • TUCAP1
  • dJ836N17.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
kinase perturbation
0.84
virus perturbation
0.76
transcription factor perturbation
0.74
transcription factor
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
71.9
body mass index
1
1
1
38.8
1
1
0
1.1
38.2
monocyte percentage of leukocytes
1
1
1
28.8
urinary albumin to creatinine ratio
2
2
2
26.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
71.9
body mass index
1
38.8
0
1.1
38.2
monocyte percentage of leukocytes
1
28.8
urinary albumin to creatinine ratio
2
26.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 9 superfamily member 4
VGNC:10492
458164
Macaque
transmembrane 9 superfamily member 4
712260
Mouse
MGI:2139220
99237
Rat
RGD:1307768
296279
Dog
transmembrane 9 superfamily member 4
VGNC:47417
477191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 9 superfamily member 4
Macaque
transmembrane 9 superfamily member 4
Mouse
Rat
Dog
transmembrane 9 superfamily member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92544-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
FAM3B
Tbio
Novelty:  0.00844967
p_int:  0.999377621
p_ni:  0.000622379
Score:  0.29
Data Source:  BioPlex,STRINGDB
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.884536292
p_ni:  0.115463708
Data Source:  BioPlex
F3
Tchem
Novelty:  0.00006457
p_int:  0.828121708
p_ni:  0.171878292
Score:  0.513
Data Source:  BioPlex,STRINGDB
TSPAN11
Tdark
Novelty:  0.37247094
p_int:  0.794339485
p_ni:  0.205660515
Score:  0.199
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
Score:  0.894
Data Source:  STRINGDB
LMAN2
Tbio
Novelty:  0.02922729
Score:  0.869
Data Source:  STRINGDB
STX12
Tbio
Novelty:  0.03836262
Score:  0.826
Data Source:  STRINGDB
STX7
Tbio
Novelty:  0.03109969
Score:  0.797
Data Source:  STRINGDB
RBBP8NL
Tdark
Novelty:  3.33075673
Score:  0.794
Data Source:  STRINGDB
PLAGL2
Tbio
Family:  TF
Novelty:  0.0161029
Score:  0.737
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.91

PubMed score by year
PubTator Score  7.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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