Protein Summary
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer ...more
- ENST00000294785
- ENSP00000294785
- ENSG00000162736
- KIAA0253
- ATAG1874
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.96 | ||
protein complex | 0.94 | ||
histone modification site profile | 0.86 | ||
cellular component | 0.78 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.26 (req: < 5)
Gene RIFs: 81 (req: <= 3)
Antibodies: 448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.26 (req: >= 5)
Gene RIFs: 81 (req: > 3)
Antibodies: 448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (177)
ACTA1
Novelty: 0.00111813
p_int: 0.999999871
p_ni: 1.29e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999845316
p_ni: 0.000154684
Score: 0.334
Data Source: BioPlex,STRINGDB
MICAL1
Family: Enzyme
Novelty: 0.02668048
p_int: 0.994293887
p_ni: 0.005658908
p_wrong: 0.000047205
Score: 0.175
Data Source: BioPlex,STRINGDB
RRAS
Family: Enzyme
Novelty: 0.00786502
p_int: 0.982687581
p_ni: 0.016975526
p_wrong: 0.000336893
Score: 0.208
Data Source: BioPlex,STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
p_int: 0.974903452
p_ni: 0.025094795
p_wrong: 0.000001753
Score: 0.205
Data Source: BioPlex,STRINGDB
PAG1
Novelty: 0.01390911
p_int: 0.945469639
p_ni: 0.05451726
p_wrong: 0.000013101
Data Source: BioPlex
EEPD1
Family: Enzyme
Novelty: 0.28148309
p_int: 0.904822289
p_ni: 0.08506369
p_wrong: 0.01011402
Score: 0.179
Data Source: BioPlex,STRINGDB
PTPRG
Family: Enzyme
Novelty: 0.01920574
p_int: 0.893194732
p_ni: 0.106805267
p_wrong: 1e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
VASN
Novelty: 0.05424159
p_int: 0.883486142
p_ni: 0.116513858
Score: 0.416
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (51)
Reactome (37)
KEGG (2)
PathwayCommons (9)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Amyloid fiber formation | ||||
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (1)
Components (15)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 60.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nicastrin | VGNC:1344 | 457435 | |||||
Macaque | nicastrin | 719696 | ||||||
Mouse | MGI:1891700 | 59287 | ||||||
Rat | RGD:631418 | 289231 | ||||||
Dog | nicastrin | VGNC:43668 | 488638 | |||||
Publication Statistics
PubMed Score 195.26
PubMed score by year
PubTator Score 84.75
PubTator score by year
Related Publications
Text Mined References (125)
GeneRif Annotations (81)
Items per page:
0 of 0
PMID | Year | Title |
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