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Tbio
LPIN2
Phosphatidate phosphatase LPIN2

Protein Summary
Description
Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261596
  • ENSP00000261596
  • ENSG00000101577

Symbol
  • KIAA0249
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
disease perturbation
0.87
kinase perturbation
0.84
biological process
0.82
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
2
2
86.7
BMI-adjusted waist-hip ratio
3
2
3
86.6
red blood cell distribution width
2
2
2
81
mean reticulocyte volume
1
1
1
64.4
apolipoprotein A 1 measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
86.7
BMI-adjusted waist-hip ratio
3
86.6
red blood cell distribution width
2
81
mean reticulocyte volume
1
64.4
apolipoprotein A 1 measurement
1
61.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipin 2
VGNC:5180
455317
Macaque
lipin 2
695641
Mouse
MGI:1891341
64898
Rat
RGD:1304588
316737
Dog
lipin 2
VGNC:42752
607640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipin 2
Macaque
lipin 2
Mouse
Rat
Dog
lipin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92539-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (153)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Glycerophospholipid biosynthesis
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Glycerophospholipid biosynthesis
M Phase
Protein-Protein Interactions (88)
1 – 10 of 88
LPIN3
Tbio
Family:  Enzyme
Novelty:  0.01641336
p_int:  1
Score:  0.954
Data Source:  BioPlex,STRINGDB
CTDNEP1
Tbio
Family:  Enzyme
Novelty:  0.09348082
Score:  0.987
Data Source:  STRINGDB
CNEP1R1
Tbio
Family:  Enzyme
Novelty:  0.68482554
Score:  0.942
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.931
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.914
Data Source:  STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.914
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.91
Data Source:  STRINGDB
LPIN1
Tbio
Family:  Enzyme
Novelty:  0.00532624
Score:  0.907
Data Source:  STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.9
Data Source:  STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.23

PubMed score by year
PubTator Score  25.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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