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Tbio
GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Protein Summary
Description
Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369983
  • ENSP00000359000
  • ENSG00000107862

Symbol
  • KIAA0248
  • ARF1GEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
drug perturbation
0.96
interacting protein
0.89
ligand (protein) perturbation
0.83
transcription factor
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.54   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.54   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
1
1
98.7
mathematical ability
3
2
3
97.9
intelligence
3
4
3
6.7
95.3
cognitive function measurement
2
1
2
89.9
sleep duration
1
1
1
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
98.7
mathematical ability
3
97.9
intelligence
3
6.7
95.3
cognitive function measurement
2
89.9
sleep duration
1
51
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi brefeldin A resistant guanine nucleotide exchange factor 1
VGNC:3864
466190
Macaque
golgi brefeldin A resistant guanine nucleotide exchange factor 1
714579
Mouse
MGI:1861607
107338
Rat
RGD:1307160
309451
Dog
golgi brefeldin A resistant guanine nucleotide exchange factor 1
VGNC:41133
486857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Macaque
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Mouse
Rat
Dog
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cargo trafficking to the periciliary membrane
Cilium Assembly
Gene Ontology Terms (39)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (208)
1 – 10 of 208
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
p_int: 0.998348475
p_ni: 0.001651525
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.987235702
p_ni: 0.012764297
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.970453732
p_ni: 0.029546268
Data Source: BioPlex
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
p_int: 0.964471272
p_ni: 0.035528728
Data Source: BioPlex
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
p_int: 0.932431383
p_ni: 0.067568617
Data Source: BioPlex
GML
Tdark
Novelty: 0.04982168
p_int: 0.918450859
p_ni: 0.08154914
Data Source: BioPlex
MILR1
Tbio
Novelty: 0.07477675
p_int: 0.912125224
p_ni: 0.087874776
Score: 0.188
Data Source: BioPlex,STRINGDB
DLK2
Tbio
Novelty: 0.06366405
p_int: 0.907714355
p_ni: 0.092285645
Data Source: BioPlex
NPY2R
Tchem
Family: GPCR
Novelty: 0.01177255
p_int: 0.858312242
p_ni: 0.141687758
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.830215452
p_ni: 0.169784548
Data Source: BioPlex
Publication Statistics
PubMed Score  9.54

PubMed score by year
PubTator Score  64.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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