You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC7A6
Y+L amino acid transporter 2

Protein Summary
Description
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219343
  • ENSP00000219343
  • ENSG00000103064
  • ENST00000566454
  • ENSP00000455064

Symbol
  • KIAA0245
  • LAT3
  • LAT-2
  • y+LAT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.81
microRNA
0.79
transcription factor binding site profile
0.78
histone modification site profile
0.71


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.66   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.66   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.6
metabolite measurement
1
1
1
80.5
glomerular filtration rate
3
2
2
6.4
58.2
serum metabolite measurement
1
1
1
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.6
metabolite measurement
1
80.5
glomerular filtration rate
2
6.4
58.2
serum metabolite measurement
1
48
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 6
VGNC:13772
743079
Mouse
MGI:2142598
330836
Rat
RGD:1309193
307811
Dog
solute carrier family 7 member 6
VGNC:46476
489744
Horse
solute carrier family 7 member 6
VGNC:51318
100066658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 6
Mouse
Rat
Dog
solute carrier family 7 member 6
Horse
solute carrier family 7 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92536-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
SLC-mediated transmembrane transport
Protein-Protein Interactions (41)
1 – 10 of 41
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.757180229
p_ni: 0.242815715
p_wrong: 0.000004056
Score: 0.199
Data Source: BioPlex,STRINGDB
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
Score: 0.975
Data Source: Reactome,STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.901
Data Source: STRINGDB
SLC43A2
Tbio
Family: Transporter
Novelty: 0.03620114
Score: 0.789
Data Source: STRINGDB
SLC3A1
Tbio
Family: Transporter
Novelty: 0.003328
Score: 0.759
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.699
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.673
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.651
Data Source: STRINGDB
SLC1A4
Tbio
Family: Transporter
Novelty: 0.01334316
Score: 0.646
Data Source: STRINGDB
CEP104
Tbio
Novelty: 0.07564892
Score: 0.64
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.66

PubMed score by year
PubTator Score  12.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer