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Tbio
PIGC
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Protein Summary
Description
Involved in GPI anchor biosynthesis (PubMed:8806613, PubMed:27694521). Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (ECO:0000269|PubMed:27694521). This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344529
  • ENSP00000356701
  • ENSG00000135845
  • ENST00000367728
  • ENSP00000356702

Symbol
  • GPI2
  • GPI2
  • MRT62
  • GPIBD16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.9
transcription factor binding site profile
0.85
transcription factor perturbation
0.8
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
2
9
99
waist-hip ratio
4
2
4
97.5
2
2
2
76.4
triglyceride measurement
2
2
3
75.7
sex hormone-binding globulin measurement
2
1
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
99
waist-hip ratio
4
97.5
2
76.4
triglyceride measurement
3
75.7
sex hormone-binding globulin measurement
2
69.1
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Protein-Protein Interactions (83)
1 – 10 of 83
PIGA
Tbio
Family: Enzyme
Novelty: 0.00172769
Score: 0.996
Data Source: STRINGDB
PIGH
Tbio
Family: Enzyme
Novelty: 0.0584561
Score: 0.996
Data Source: STRINGDB
PIGQ
Tbio
Family: Enzyme
Novelty: 0.02701629
Score: 0.994
Data Source: STRINGDB
PIGP
Tbio
Family: Enzyme
Novelty: 0.01400934
Score: 0.991
Data Source: STRINGDB
DPM2
Tdark
Novelty: 0.04752556
Score: 0.989
Data Source: STRINGDB
PIGL
Tbio
Family: Enzyme
Novelty: 0.03151013
Score: 0.987
Data Source: STRINGDB
PIGY
Tbio
Family: Enzyme
Novelty: 0.17988252
Score: 0.974
Data Source: STRINGDB
PYURF
Tdark
Novelty: 0.19841169
Score: 0.928
Data Source: STRINGDB
PIGB
Tbio
Family: Enzyme
Novelty: 0.05237713
Score: 0.911
Data Source: STRINGDB
PIGM
Tbio
Family: Enzyme
Novelty: 0.02186069
Score: 0.877
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.60

PubMed score by year
PubTator Score  13.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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