Tbio PIGC Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Protein Summary

Description

Involved in GPI anchor biosynthesis (PubMed:8806613, PubMed:27694521). Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (ECO:0000269|PubMed:27694521). This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92535
• O14491

Gene Name

• PIGC

Ensembl ID

• ENST00000344529
• ENSP00000356701
• ENSG00000135845
• ENST00000367728
• ENSP00000356702

Symbol

• GPI2
• GPI2
• MRT62
• GPIBD16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
virus perturbation	0.9
transcription factor binding site profile	0.85
transcription factor perturbation	0.8
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Phosphatidylinositol N-acetylglucosaminyltransferase Subunit C

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Phosphatidylinositol N-acetylglucosaminyltransferase Subunit C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0