You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PSMF1
Proteasome inhibitor PI31 subunit

Protein Summary
Description
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333082
  • ENSP00000327704
  • ENSG00000125818
  • ENST00000335877
  • ENSP00000338039

Symbol
  • PI31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
pathway
1
biological process
0.99
disease perturbation
0.99
co-expressed gene
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome inhibitor subunit 1
VGNC:6252
458030
Macaque
proteasome inhibitor subunit 1
715314
Mouse
MGI:1346072
228769
Rat
RGD:1587528
689852
Dog
proteasome inhibitor subunit 1
VGNC:45120
477184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome inhibitor subunit 1
Macaque
proteasome inhibitor subunit 1
Mouse
Rat
Dog
proteasome inhibitor subunit 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92530-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (149)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Protein-Protein Interactions (233)
1 – 10 of 233
FBXO7
Tbio
Novelty: 0.01151907
p_int: 0.999998883
p_ni: 0.00000111
p_wrong: 7e-9
Score: 0.889
Data Source: BioPlex,STRINGDB
PSMG2
Tbio
Novelty: 0.11082503
p_int: 0.999980186
p_ni: 0.000019814
Score: 0.85
Data Source: BioPlex,STRINGDB
PSMB1
Tclin
Family: Enzyme
Novelty: 0.0255917
p_int: 0.999969406
p_ni: 0.000030594
Score: 0.983
Data Source: BioPlex,STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.03862668
p_int: 0.999968214
p_ni: 0.000031786
Score: 0.924
Data Source: BioPlex,STRINGDB
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
p_int: 0.999958594
p_ni: 0.000041404
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999853399
p_ni: 0.0001466
Score: 0.987
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.999759857
p_ni: 0.000240143
Score: 0.986
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.999313377
p_ni: 0.000686616
p_wrong: 7e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.998955327
p_ni: 0.001044672
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.996548435
p_ni: 0.002562772
p_wrong: 0.000888793
Score: 0.939
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.34

PubMed score by year
PubTator Score  12.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer