Tbio SHC3 SHC-transforming protein 3

Protein Summary

Description

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Uniprot Accession IDs

• Q92529
• Q5T7I7
• Q8TAP2
• Q9UCX5

Gene Name

• SHC3

Ensembl ID

• ENST00000375835
• ENSP00000364995
• ENSG00000148082

Symbol

• NSHC
• SHCC
• RAI
• NSHC
• SHCC
• N-Shc

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.75
protein domain	0.73
transcription factor	0.72
virus perturbation	0.72
transcription factor binding site profile	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Shc-transforming Protein 3

DTO Classes

Protein / Signaling / Shc-transforming Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.57   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.57   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0