Tbio SHC3 SHC-transforming protein 3

Protein Summary

Description

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Uniprot Accession IDs

• Q92529
• Q5T7I7
• Q8TAP2
• Q9UCX5

Gene Name

• SHC3

Ensembl ID

• ENST00000375835
• ENSP00000364995
• ENSG00000148082

Symbol

• NSHC
• SHCC
• RAI
• NSHC
• SHCC
• N-Shc

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.75
protein domain	0.73
transcription factor	0.72
virus perturbation	0.72
transcription factor binding site profile	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Shc-transforming Protein 3

DTO Classes

Protein / Signaling / Shc-transforming Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.21   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.21   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

• See Interactions on String-DB

SHC4

Tbio

Novelty:  0.04623367

p_int:  0.933015105

p_ni:  1e-9

p_wrong:  0.066984894

Score:  0.71

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

Score:  0.993

Data Source:  Reactome,STRINGDB

NTRK1

Tclin

Family:  Kinase

Novelty:  0.00033453

Score:  0.988

Data Source:  Reactome,STRINGDB

NTRK2

Tclin

Family:  Kinase

Novelty:  0.00054534

Score:  0.987

Data Source:  STRINGDB

RET

Tclin

Family:  Kinase

Novelty:  0.00028324

Score:  0.955

Data Source:  STRINGDB

EGFR

Tclin

Family:  Kinase

Novelty:  0.00007274

Score:  0.935

Data Source:  STRINGDB

NGF

Tchem

Novelty:  0.00008139

Score:  0.935

Data Source:  Reactome,STRINGDB

BDNF

Tchem

Novelty:  0.00006891

Score:  0.932

Data Source:  STRINGDB

NTRK3

Tclin

Family:  Kinase

Novelty:  0.00177321

Score:  0.926

Data Source:  STRINGDB

SOS1

Tchem

Novelty:  0.00285343

Score:  0.924

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (28)

Explore Nearest Tclin Targets

Upstream (27)

Downstream (1)

1 – 5 of 27

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  7

1: EGFR tyrosine kinase inhibitor resistance

2: Endocrine resistance

3: Focal adhesion

4: Breast cancer

more:  3 more common pathways

MET

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  6

1: EGFR tyrosine kinase inhibitor resistance

2: Gastric cancer

3: Focal adhesion

4: Hepatocellular carcinoma

more:  2 more common pathways

FGFR2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  3

1: EGFR tyrosine kinase inhibitor resistance

2: Gastric cancer

3: Ras signaling pathway

PDGFRB

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  5

1: EGFR tyrosine kinase inhibitor resistance

2: Focal adhesion

3: Ras signaling pathway

4: Phospholipase D signaling pathway

5: Glioma

FGFR3

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  2

1: EGFR tyrosine kinase inhibitor resistance

2: Ras signaling pathway

Pathways (59)

Reactome (17)

KEGG (20)

PathwayCommons (13)

WikiPathways (9)

Axon guidance (R-HSA-422475)

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Find Similar Targets

Items per page:

5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Developmental Biology	1055 targets	R-HSA-1266738
FLT3 Signaling	264 targets	R-HSA-9607240
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (3)

Components (2)

Processes (8)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
phosphotyrosine residue binding	Inferred from Physical Interaction (IPI)	CAFA
receptor tyrosine kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	3	3		93
monocyte count	EFO_0005091	3	4	4		92
HbA1c measurement	EFO_0004541	1	2	2		85.6
myeloid white cell count	EFO_0007988	1	1	1		27.9
leukocyte count	EFO_0004308	2	2	2		21.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	3		93
monocyte count	EFO_0005091	4		92
HbA1c measurement	EFO_0004541	2		85.6
myeloid white cell count	EFO_0007988	1		27.9
leukocyte count	EFO_0004308	2		21.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome
SH2 domain

GWAS Trait Find Similar Targets

No Header	No Header
bilirubin measurement
granulocyte percentage of myeloid white cells
HbA1c measurement
leukocyte count
monocyte count
monocyte percentage of leukocytes
myeloid white cell count

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	src homology 2 domain-containing transforming protein C3	MGI:106179	20418
Rat	SHC adaptor protein 3	RGD:69348	114858
Dog	SHC adaptor protein 3	VGNC:46141	476352
Horse	SHC adaptor protein 3	VGNC:22956	100061926
Cow	SHC adaptor protein 3	VGNC:34591	512696

Species	Name	OMA	EggNOG	Inparanoid
Mouse	src homology 2 domain-containing transforming protein C3
Rat	SHC adaptor protein 3
Dog	SHC adaptor protein 3
Horse	SHC adaptor protein 3
Cow	SHC adaptor protein 3

Publication Statistics

PubMed Score 32.21

PubMed score by year

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PubTator Score 33.79

PubTator score by year

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Related Publications

Text Mined References (35)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title