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Tbio
SHC3
SHC-transforming protein 3

Protein Classes
Protein Summary
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375835
  • ENSP00000364995
  • ENSG00000148082

Symbol
  • NSHC
  • SHCC
  • RAI
  • NSHC
  • SHCC
  • N-Shc
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.75
protein domain
0.73
transcription factor
0.72
virus perturbation
0.72
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.16   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.16   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
27.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106179
20418
Rat
RGD:69348
114858
Dog
SHC adaptor protein 3
VGNC:46141
476352
Horse
SHC adaptor protein 3
VGNC:22956
100061926
Cow
SHC adaptor protein 3
VGNC:34591
512696
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SHC adaptor protein 3
Horse
SHC adaptor protein 3
Cow
SHC adaptor protein 3
Pathways (59)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Protein-Protein Interactions (97)
1 – 10 of 97
SHC4
Tbio
Novelty: 0.04623367
p_int: 0.933015105
p_ni: 1e-9
p_wrong: 0.066984894
Score: 0.71
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.993
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.988
Data Source: Reactome,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.987
Data Source: STRINGDB
RET
Tclin
Family: Kinase
Novelty: 0.00028324
Score: 0.955
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.935
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.935
Data Source: Reactome,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.932
Data Source: STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.926
Data Source: STRINGDB
SOS1
Tbio
Novelty: 0.00285343
Score: 0.924
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  31.16

PubMed score by year
PubTator Score  33.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer