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Tchem
CPT1B
Carnitine O-palmitoyltransferase 1, muscle isoform

Protein Summary
Description
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312108
  • ENSP00000312189
  • ENSG00000205560
  • ENST00000360719
  • ENSP00000353945
  • ENST00000395650
  • ENSP00000379011
  • ENST00000405237
  • ENSP00000385486
  • ENST00000457250
  • ENSP00000409342

Symbol
  • KIAA1670
  • CPTI
  • CPT1M
  • MCPT1
  • CPT1-M
  • CPTI-M
  • M-CPT1
  • MCCPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
virus perturbation
0.99
cellular component
0.86
disease
0.6
biological process
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 50
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 1B
VGNC:5976
470253
Macaque
carnitine palmitoyltransferase 1B
720697
Mouse
MGI:1098297
12895
Rat
RGD:2397
25756
Dog
carnitine palmitoyltransferase 1B
VGNC:39580
481184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 1B
Macaque
carnitine palmitoyltransferase 1B
Mouse
Rat
Dog
carnitine palmitoyltransferase 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92523-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (43)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Metabolism of lipids
Signal Transduction
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (99)
1 – 10 of 99
CPT2
Tchem
Family: Enzyme
Novelty: 0.00345645
Score: 0.934
Data Source: STRINGDB
CHKB
Tbio
Family: Kinase
Novelty: 0.00862294
Score: 0.922
Data Source: STRINGDB
CRAT
Tbio
Family: Enzyme
Novelty: 0.01242609
Score: 0.922
Data Source: STRINGDB
ACACB
Tchem
Family: Enzyme
Novelty: 0.00462116
Score: 0.918
Data Source: STRINGDB
SLC25A20
Tbio
Family: Transporter
Novelty: 0.00503518
Score: 0.908
Data Source: STRINGDB
CPT1C
Tbio
Family: Enzyme
Novelty: 0.01024583
Score: 0.809
Data Source: STRINGDB
CPT1A
Tchem
Family: Enzyme
Novelty: 0.00281783
Score: 0.808
Data Source: STRINGDB
ACSL1
Tbio
Family: Enzyme
Novelty: 0.00336161
Score: 0.804
Data Source: STRINGDB
ACSL3
Tbio
Family: Enzyme
Novelty: 0.01772336
Score: 0.767
Data Source: STRINGDB
ACSL5
Tbio
Family: Enzyme
Novelty: 0.00850919
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.13

PubMed score by year
PubTator Score  200.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer