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Tbio
H1FX
Histone H1x

Protein Summary
Description
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333762
  • ENSP00000329662
  • ENSG00000184897

Symbol
  • H1X
  • H1.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.72
transcription factor binding site profile
0.71
cellular component
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
H1F0
Tchem
Novelty: 0.00039686
Score: 0.993
Data Source: STRINGDB
H1FOO
Tbio
Novelty: 0.02189067
Score: 0.974
Data Source: STRINGDB
RSL1D1
Tbio
Novelty: 0.04525424
Score: 0.936
Data Source: STRINGDB
HMGB2
Tbio
Family: TF
Novelty: 0.01761676
Score: 0.915
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.915
Data Source: STRINGDB
DFFB
Tbio
Novelty: 0.00475349
Score: 0.9
Data Source: STRINGDB
RRP12
Tbio
Novelty: 0.10034381
Score: 0.848
Data Source: STRINGDB
H1FNT
Tdark
Novelty: 0.05593238
Score: 0.786
Data Source: STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
Score: 0.722
Data Source: STRINGDB
HIST1H1T
Tdark
Novelty: 0.01039464
Score: 0.705
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.24

PubMed score by year
PubTator Score  9.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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