Tbio H1FX Histone H1x

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H1x

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H1x

Protein Summary

Description

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q92522

Gene Name

• H1FX

Ensembl ID

• ENST00000333762
• ENSP00000329662
• ENSG00000184897

Symbol

• H1X
• H1.10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
gene perturbation	0.72
transcription factor binding site profile	0.71
cellular component	0.7
disease perturbation	0.68

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.24   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	H1 histone family member X	VGNC:14242	100608292
Mouse	H1 histone family, member X	MGI:2685307	243529
Rat	H1 histone family, member X	RGD:1565596	500252
Cow	H1 histone family, member X		511901
Pig	histone H1x		100516295

Species	Name	OMA	EggNOG	Inparanoid
Chimp	H1 histone family member X
Mouse	H1 histone family, member X
Rat	H1 histone family, member X
Cow	H1 histone family, member X
Pig	histone H1x

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92522-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (13)

Functions (4)

Components (3)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
double-stranded DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleosomal DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (45)

Explore Interacting Targets

1 – 10 of 45

• See Interactions on String-DB

H1F0

Tchem

Novelty: 0.00039686

Score: 0.993

Data Source: STRINGDB

H1FOO

Tbio

Novelty: 0.02189067

Score: 0.974

Data Source: STRINGDB

RSL1D1

Tbio

Novelty: 0.04525424

Score: 0.936

Data Source: STRINGDB

HMGB2

Tbio

Family: TF

Novelty: 0.01761676

Score: 0.915

Data Source: STRINGDB

HMGB1

Tbio

Family: TF

Novelty: 0.00043845

Score: 0.915

Data Source: STRINGDB

DFFB

Tbio

Novelty: 0.00475349

Score: 0.9

Data Source: STRINGDB

RRP12

Tbio

Novelty: 0.10034381

Score: 0.848

Data Source: STRINGDB

H1FNT

Tdark

Novelty: 0.05593238

Score: 0.786

Data Source: STRINGDB

H2AFY2

Tbio

Novelty: 0.09948698

Score: 0.722

Data Source: STRINGDB

HIST1H1T

Tdark

Novelty: 0.01039464

Score: 0.705

Data Source: STRINGDB

Publication Statistics

PubMed Score  39.24

PubMed score by year

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PubTator Score  9.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Chromosome
Citrullination
Complete proteome
Direct protein sequencing
DNA-binding
Nucleus
Phosphoprotein
Reference proteome

MGI Phenotype Find Similar Targets

adipose tissue phenotype
cardiovascular system phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
nervous system phenotype