Protein Summary
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
- ENST00000359943
- ENSP00000353025
- ENSG00000196937
- ILEI
- ILEI
- GS3786
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor binding site profile | 0.89 | ||
microRNA | 0.81 | ||
histone modification site profile | 0.76 | ||
transcription factor perturbation | 0.74 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.7 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.7 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Gene Ontology Terms (8)
Functions (1)
Components (4)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (59)
1 – 10 of 59
MICB
Novelty: 0.00776922
p_int: 0.999206102
p_ni: 0.000793879
p_wrong: 2e-8
Data Source: BioPlex
ST3GAL4
Family: Enzyme
Novelty: 0.00556568
p_int: 0.998400034
p_ni: 0.001104246
p_wrong: 0.000495721
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC52
Family: IC
Novelty: 0.4058938
p_int: 0.998135471
p_ni: 0.001864488
p_wrong: 4.1e-8
Data Source: BioPlex
IFNLR1
Novelty: 0.02567087
p_int: 0.997547146
p_ni: 0.002448787
p_wrong: 0.000004067
Data Source: BioPlex
B3GNT2
Family: Enzyme
Novelty: 0.03469416
p_int: 0.994769789
p_ni: 0.005229844
p_wrong: 3.67e-7
Score: 0.174
Data Source: BioPlex,STRINGDB
TMEM106A
Novelty: 0.49469965
p_int: 0.985819514
p_ni: 0.00669962
p_wrong: 0.007480866
Data Source: BioPlex
CHST6
Family: Enzyme
Novelty: 0.02270215
p_int: 0.984863453
p_ni: 0.010433398
p_wrong: 0.004703149
Score: 0.183
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.38877844
p_int: 0.966257618
p_ni: 0.015406747
p_wrong: 0.018335635
Data Source: BioPlex
B3GALNT1
Family: Enzyme
Novelty: 0.00535685
p_int: 0.943027647
p_ni: 0.036084023
p_wrong: 0.02088833
Score: 0.166
Data Source: BioPlex,STRINGDB
PDCD1
Novelty: 0.00079757
p_int: 0.920099728
p_ni: 0.079892058
p_wrong: 0.000008215
Data Source: BioPlex
Publication Statistics
PubMed Score 66.70
PubMed score by year
PubTator Score 15.96
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait