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Tbio
FAM3C
Protein FAM3C

Protein Summary
Description
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359943
  • ENSP00000353025
  • ENSG00000196937

Symbol
  • ILEI
  • ILEI
  • GS3786
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.89
microRNA
0.81
histone modification site profile
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.7   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.7   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
MICB
Tbio
Novelty: 0.00776922
p_int: 0.999206102
p_ni: 0.000793879
p_wrong: 2e-8
Data Source: BioPlex
ST3GAL4
Tbio
Family: Enzyme
Novelty: 0.00556568
p_int: 0.998400034
p_ni: 0.001104246
p_wrong: 0.000495721
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC52
Tbio
Family: IC
Novelty: 0.4058938
p_int: 0.998135471
p_ni: 0.001864488
p_wrong: 4.1e-8
Data Source: BioPlex
IFNLR1
Tbio
Novelty: 0.02567087
p_int: 0.997547146
p_ni: 0.002448787
p_wrong: 0.000004067
Data Source: BioPlex
B3GNT2
Tbio
Family: Enzyme
Novelty: 0.03469416
p_int: 0.994769789
p_ni: 0.005229844
p_wrong: 3.67e-7
Score: 0.174
Data Source: BioPlex,STRINGDB
TMEM106A
Tdark
Novelty: 0.49469965
p_int: 0.985819514
p_ni: 0.00669962
p_wrong: 0.007480866
Data Source: BioPlex
CHST6
Tbio
Family: Enzyme
Novelty: 0.02270215
p_int: 0.984863453
p_ni: 0.010433398
p_wrong: 0.004703149
Score: 0.183
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.38877844
p_int: 0.966257618
p_ni: 0.015406747
p_wrong: 0.018335635
Data Source: BioPlex
B3GALNT1
Tbio
Family: Enzyme
Novelty: 0.00535685
p_int: 0.943027647
p_ni: 0.036084023
p_wrong: 0.02088833
Score: 0.166
Data Source: BioPlex,STRINGDB
PDCD1
Tclin
Novelty: 0.00079757
p_int: 0.920099728
p_ni: 0.079892058
p_wrong: 0.000008215
Data Source: BioPlex
Publication Statistics
PubMed Score  66.70

PubMed score by year
PubTator Score  15.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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