HSD17B8
Estradiol 17-beta-dehydrogenase 8
Protein Summary
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of t ...more
- ENST00000230236
- ENSP00000230236
- ENSG00000112474
- ENST00000374662
- ENSP00000363794
- ENSG00000204228
- ENST00000414463
- ENSP00000387753
- ENSG00000228357
- ENST00000422433
- ENSP00000406488
- ENSG00000232357
- ENST00000427295
- ENSP00000403538
- ENSG00000228712
- ENST00000454191
- ENSP00000413950
- ENSG00000225312
- FABGL
- HKE6
- RING2
- SDR30C1
- KE6
- FABG
- HKE6
- FABGL
- RING2
- H2-KE6
- SDR30C1
- D6S2245E
- dJ1033B10.9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
cell type or tissue | 0.73 | ||
protein domain | 0.58 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.63 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 197 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.63 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 197 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0