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Tbio
HSD17B8
Estradiol 17-beta-dehydrogenase 8

Protein Summary
Description
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230236
  • ENSP00000230236
  • ENSG00000112474
  • ENST00000374662
  • ENSP00000363794
  • ENSG00000204228
  • ENST00000414463
  • ENSP00000387753
  • ENSG00000228357
  • ENST00000422433
  • ENSP00000406488
  • ENSG00000232357
  • ENST00000427295
  • ENSP00000403538
  • ENSG00000228712
  • ENST00000454191
  • ENSP00000413950
  • ENSG00000225312

Symbol
  • FABGL
  • HKE6
  • RING2
  • SDR30C1
  • KE6
  • FABG
  • HKE6
  • FABGL
  • RING2
  • H2-KE6
  • SDR30C1
  • D6S2245E
  • dJ1033B10.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.84
cell type or tissue
0.73
protein domain
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (118)
1 – 10 of 118
MOCOS
Tbio
Family:  Enzyme
Novelty:  0.05022905
p_int:  0.999999558
p_ni:  4.41e-7
p_wrong:  1e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.999992259
p_ni:  0.000005136
p_wrong:  0.000002606
Data Source:  BioPlex
HNRNPF
Tbio
Novelty:  0.01833966
p_int:  0.999963113
p_ni:  0.000036887
Score:  0.171
Data Source:  BioPlex,STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999932539
p_ni:  0.000051255
p_wrong:  0.000016206
Data Source:  BioPlex
ANGPTL7
Tbio
Novelty:  0.03893082
p_int:  0.999930433
p_ni:  0.00006442
p_wrong:  0.000005148
Score:  0.163
Data Source:  BioPlex,STRINGDB
CBR4
Tbio
Family:  Enzyme
Novelty:  0.0941099
p_int:  0.999900067
p_ni:  0.000099933
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.999822742
p_ni:  0.000045395
p_wrong:  0.000131862
Data Source:  BioPlex
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999442524
p_ni:  3.58e-7
p_wrong:  0.000557118
Score:  0.519
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.988504326
p_ni:  0.010164265
p_wrong:  0.001331409
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.98774836
p_ni:  0.000746055
p_wrong:  0.011505586
Score:  0.237
Data Source:  BioPlex,STRINGDB
Pathways (10)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.3
92.3
3
4
0
1.3
92.3
3
4
0
1.3
92.3
3
4
0
1.3
92.3
1
1
0
1.6
76.6
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92.3
0
1.3
92.3
0
1.3
92.3
0
1.3
92.3
0
1.6
76.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hydroxysteroid 17-beta dehydrogenase 8
718119
Mouse
MGI:95911
14979
Rat
RGD:1303158
361802
Dog
hydroxysteroid 17-beta dehydrogenase 8
VGNC:41810
607895
Horse
hydroxysteroid 17-beta dehydrogenase 8
VGNC:18889
100061414
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hydroxysteroid 17-beta dehydrogenase 8
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 8
Horse
hydroxysteroid 17-beta dehydrogenase 8
Publication Statistics
PubMed Score 113.83
PubMed score by year
PubTator Score 20.52
PubTator score by year