Tbio SLC39A7 Zinc transporter SLC39A7

Protein Summary

Description

Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q92504
• B0UXF6
• Q5STP8
• Q9UIQ0

Gene Name

• SLC39A7

Ensembl ID

• ENST00000374675
• ENSP00000363807
• ENSG00000112473
• ENST00000374677
• ENSP00000363809
• ENST00000383213
• ENSP00000372700
• ENSG00000206288
• ENST00000383214
• ENSP00000372701
• ENST00000416369
• ENSP00000403583
• ENSG00000229802
• ENST00000418477
• ENSP00000416439
• ENSG00000226614
• ENST00000423043
• ENSP00000389623
• ENST00000431735
• ENSP00000410656
• ENSG00000224399
• ENST00000441854
• ENSP00000391735
• ENST00000441953
• ENSP00000413027
• ENST00000443773
• ENSP00000407093
• ENSG00000227402
• ENST00000456261
• ENSP00000414145

Symbol

• HKE4
• RING5
• KE4
• HKE4
• ZIP7
• RING5
• H2-KE4
• D6S115E
• D6S2244E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.64
small molecule perturbation	0.63
tissue sample	0.63
cell line	0.6
interacting protein	0.58

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Zinc Transporter Slc39a7

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Slc39a7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0