SLC39A7
Zinc transporter SLC39A7
Protein Summary
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000374675
- ENSP00000363807
- ENSG00000112473
- ENST00000374677
- ENSP00000363809
- ENST00000383213
- ENSP00000372700
- ENSG00000206288
- ENST00000383214
- ENSP00000372701
- ENST00000416369
- ENSP00000403583
- ENSG00000229802
- ENST00000418477
- ENSP00000416439
- ENSG00000226614
- ENST00000423043
- ENSP00000389623
- ENST00000431735
- ENSP00000410656
- ENSG00000224399
- ENST00000441854
- ENSP00000391735
- ENST00000441953
- ENSP00000413027
- ENST00000443773
- ENSP00000407093
- ENSG00000227402
- ENST00000456261
- ENSP00000414145
- HKE4
- RING5
- KE4
- HKE4
- ZIP7
- RING5
- H2-KE4
- D6S115E
- D6S2244E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.64 | ||
small molecule perturbation | 0.63 | ||
tissue sample | 0.63 | ||
cell line | 0.6 | ||
interacting protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 81.91 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 227 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 81.91 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 227 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (80)
Nearest Tclin Targets
Pathways (9)
Reactome (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metal ion SLC transporters | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Reactome | Transport of small molecules | ||||
Reactome | Zinc influx into cells by the SLC39 gene family | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metal ion SLC transporters | ||||
SLC-mediated transmembrane transport | ||||
Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Transport of small molecules | ||||
Zinc influx into cells by the SLC39 gene family | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (110)
Items per page:
1 – 5 of 110
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
4 | 5 | 1 | 1.3 | 97.6 | ||||||
4 | 5 | 1 | 1.3 | 97.6 | ||||||
4 | 5 | 1 | 1.3 | 97.6 | ||||||
4 | 5 | 1 | 1.3 | 97.6 | ||||||
4 | 5 | 1 | 1.3 | 97.6 | ||||||
Items per page:
1 – 5 of 110
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.3 | 97.6 | |||||
1 | 1.3 | 97.6 | |||||
1 | 1.3 | 97.6 | |||||
1 | 1.3 | 97.6 | |||||
1 | 1.3 | 97.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | solute carrier family 39 member 7 | 100430704 | ||||||
Mouse | MGI:95909 | 14977 | ||||||
Rat | RGD:1593280 | 294281 | ||||||
Dog | solute carrier family 39 member 7 | VGNC:46406 | 481736 | |||||
Horse | solute carrier family 39 member 7 | VGNC:23207 | 100061379 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | solute carrier family 39 member 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 39 member 7 | |||||
Horse | solute carrier family 39 member 7 | |||||
Publication Statistics
PubMed Score 81.91
PubMed score by year
PubTator Score 21.29
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (12)
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0 of 0
PMID | Year | Title |
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