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Tbio
SLC39A7
Zinc transporter SLC39A7

Protein Summary
Description
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374675
  • ENSP00000363807
  • ENSG00000112473
  • ENST00000374677
  • ENSP00000363809
  • ENST00000383213
  • ENSP00000372700
  • ENSG00000206288
  • ENST00000383214
  • ENSP00000372701
  • ENST00000416369
  • ENSP00000403583
  • ENSG00000229802
  • ENST00000418477
  • ENSP00000416439
  • ENSG00000226614
  • ENST00000423043
  • ENSP00000389623
  • ENST00000431735
  • ENSP00000410656
  • ENSG00000224399
  • ENST00000441854
  • ENSP00000391735
  • ENST00000441953
  • ENSP00000413027
  • ENST00000443773
  • ENSP00000407093
  • ENSG00000227402
  • ENST00000456261
  • ENSP00000414145

Symbol
  • HKE4
  • RING5
  • KE4
  • HKE4
  • ZIP7
  • RING5
  • H2-KE4
  • D6S115E
  • D6S2244E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.64
small molecule perturbation
0.63
tissue sample
0.63
cell line
0.6
interacting protein
0.58


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 39 member 7
100430704
Mouse
MGI:95909
14977
Rat
RGD:1593280
294281
Dog
solute carrier family 39 member 7
VGNC:46406
481736
Horse
solute carrier family 39 member 7
VGNC:23207
100061379
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 39 member 7
Mouse
Rat
Dog
solute carrier family 39 member 7
Horse
solute carrier family 39 member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92504-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (80)
1 – 10 of 80
SLC39A1
Tbio
Family: Transporter
Novelty: 0.00678191
Score: 0.903
Data Source: STRINGDB
SLC30A7
Tbio
Family: Transporter
Novelty: 0.02998245
Score: 0.889
Data Source: STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.884
Data Source: STRINGDB
SLC30A5
Tbio
Family: Transporter
Novelty: 0.02432633
Score: 0.875
Data Source: STRINGDB
SLC39A2
Tbio
Family: Transporter
Novelty: 0.01886854
Score: 0.875
Data Source: STRINGDB
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
Score: 0.85
Data Source: STRINGDB
SLC30A6
Tbio
Family: Transporter
Novelty: 0.06083299
Score: 0.842
Data Source: STRINGDB
HSD17B8
Tbio
Family: Enzyme
Novelty: 0.00915958
Score: 0.838
Data Source: STRINGDB
SLC30A10
Tbio
Family: Transporter
Novelty: 0.00448153
Score: 0.835
Data Source: STRINGDB
KIFC1
Tchem
Novelty: 0.00982095
Score: 0.816
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.71

PubMed score by year
PubTator Score  21.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer