Tbio SLC39A7 Zinc transporter SLC39A7

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Zinc Transporter Slc39a7

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Slc39a7

Protein Summary

Description

Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q92504
• B0UXF6
• Q5STP8
• Q9UIQ0

Gene Name

• SLC39A7

Ensembl ID

• ENST00000374675
• ENSP00000363807
• ENSG00000112473
• ENST00000374677
• ENSP00000363809
• ENST00000383213
• ENSP00000372700
• ENSG00000206288
• ENST00000383214
• ENSP00000372701
• ENST00000416369
• ENSP00000403583
• ENSG00000229802
• ENST00000418477
• ENSP00000416439
• ENSG00000226614
• ENST00000423043
• ENSP00000389623
• ENST00000431735
• ENSP00000410656
• ENSG00000224399
• ENST00000441854
• ENSP00000391735
• ENST00000441953
• ENSP00000413027
• ENST00000443773
• ENSP00000407093
• ENSG00000227402
• ENST00000456261
• ENSP00000414145

Symbol

• HKE4
• RING5
• KE4
• HKE4
• ZIP7
• RING5
• H2-KE4
• D6S115E
• D6S2244E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.64
small molecule perturbation	0.63
tissue sample	0.63
cell line	0.6
interacting protein	0.58

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 39 member 7		100430704
Mouse	solute carrier family 39 (zinc transporter), member 7	MGI:95909	14977
Rat	solute carrier family 39 member 7	RGD:1593280	294281
Dog	solute carrier family 39 member 7	VGNC:46406	481736
Horse	solute carrier family 39 member 7	VGNC:23207	100061379

Species	Name	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 39 member 7
Mouse	solute carrier family 39 (zinc transporter), member 7
Rat	solute carrier family 39 member 7
Dog	solute carrier family 39 member 7
Horse	solute carrier family 39 member 7

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q92504-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)

Reactome (6)

WikiPathways (3)

Metal ion SLC transporters (R-HSA-425410)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metal ion SLC transporters	26 targets	R-HSA-425410
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551
Reactome	Zinc influx into cells by the SLC39 gene family	10 targets	R-HSA-442380

Name	Explore in Pharos	Explore in Source
Metal ion SLC transporters	26 targets	R-HSA-425410
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551
Zinc influx into cells by the SLC39 gene family	10 targets	R-HSA-442380

Gene Ontology Terms (9)

Functions (1)

Components (6)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (80)

Explore Interacting Targets

1 – 10 of 80

• See Interactions on String-DB

SLC39A1

Tbio

Family: Transporter

Novelty: 0.00678191

Score: 0.903

Data Source: STRINGDB

SLC30A7

Tbio

Family: Transporter

Novelty: 0.02998245

Score: 0.889

Data Source: STRINGDB

SLC39A9

Tbio

Family: Transporter

Novelty: 0.06143625

Score: 0.884

Data Source: STRINGDB

SLC30A5

Tbio

Family: Transporter

Novelty: 0.02432633

Score: 0.875

Data Source: STRINGDB

SLC39A2

Tbio

Family: Transporter

Novelty: 0.01886854

Score: 0.875

Data Source: STRINGDB

SLC30A1

Tbio

Family: Transporter

Novelty: 0.00528427

Score: 0.85

Data Source: STRINGDB

SLC30A6

Tbio

Family: Transporter

Novelty: 0.06083299

Score: 0.842

Data Source: STRINGDB

HSD17B8

Tbio

Family: Enzyme

Novelty: 0.00915958

Score: 0.838

Data Source: STRINGDB

SLC30A10

Tbio

Family: Transporter

Novelty: 0.00448153

Score: 0.835

Data Source: STRINGDB

KIFC1

Tchem

Novelty: 0.00982095

Score: 0.816

Data Source: STRINGDB

Publication Statistics

PubMed Score  63.71

PubMed score by year

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PubTator Score  21.29

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Complete proteome
Endoplasmic reticulum
Golgi apparatus
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

MGI Phenotype Find Similar Targets

cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
mortality/aging