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Tbio
STARD8
StAR-related lipid transfer protein 8

Protein Summary
Description
Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252336
  • ENSP00000252336
  • ENSG00000130052
  • ENST00000374597
  • ENSP00000363725
  • ENST00000374599
  • ENSP00000363727

Symbol
  • DLC3
  • KIAA0189
  • DLC3
  • ARHGAP38
  • STARTGAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
tissue sample
0.66
PubMedID
0.61
small molecule perturbation
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.946
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.934
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.931
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.928
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.914
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.91
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.91
Data Source:  STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
Score:  0.907
Data Source:  STRINGDB
RHOBTB1
Tbio
Novelty:  0.02152609
Score:  0.907
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
84.6
platelet count
1
1
1
79.1
testosterone measurement
2
1
2
49.5
balding measurement
1
1
1
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
84.6
platelet count
1
79.1
testosterone measurement
2
49.5
balding measurement
1
34.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
StAR related lipid transfer domain containing 8
VGNC:11629
465682
Macaque
StAR related lipid transfer domain containing 8
693629
Mouse
MGI:2448556
236920
Rat
RGD:1560770
312113
Dog
StAR related lipid transfer domain containing 8
VGNC:46888
491932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
StAR related lipid transfer domain containing 8
Macaque
StAR related lipid transfer domain containing 8
Mouse
Rat
Dog
StAR related lipid transfer domain containing 8
Publication Statistics
PubMed Score 24.24
PubMed score by year
PubTator Score 6.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title