Tbio SMPDL3B Acid sphingomyelinase-like phosphodiesterase 3b

Protein Summary

Description

Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).

Uniprot Accession IDs

• Q92485
• B7ZB35
• Q5T0Z0
• Q96CB7
• ASM-like phosphodiesterase 3b

Gene Name

• SMPDL3B

Ensembl ID

• ENST00000373888
• ENSP00000362995
• ENSG00000130768
• ENST00000373894
• ENSP00000363001

Symbol

• ASML3B
• ASMLPD
• ASML3B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
gene perturbation	0.76
small molecule perturbation	0.61
tissue sample	0.61
PubMedID	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphodiesterase / Acid Sphingomyelinase-like Phosphodiesterase 3b

DTO Classes

Protein / Enzyme / Hydrolase / Phosphodiesterase / Acid Sphingomyelinase-like Phosphodiesterase 3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0