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Tbio
SMPDL3A
Acid sphingomyelinase-like phosphodiesterase 3a

Protein Summary
Description
Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368440
  • ENSP00000357425
  • ENSG00000172594
  • ENST00000539041
  • ENSP00000442152

Symbol
  • ASML3A
  • ASM3A
  • ASML3a
  • yR36GH4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
disease perturbation
0.93
transcription factor perturbation
0.88
PubMedID
0.85
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
BRINP1
Tbio
Novelty: 0.06032357
Score: 0.99
Data Source: STRINGDB
PRF1
Tchem
Novelty: 0.00035268
Score: 0.713
Data Source: STRINGDB
TTC23
Tdark
Novelty: 3.41463415
Score: 0.713
Data Source: STRINGDB
CMBL
Tbio
Family: Enzyme
Novelty: 0.01106029
Score: 0.663
Data Source: STRINGDB
APTX
Tbio
Novelty: 0.00941154
Score: 0.577
Data Source: STRINGDB
TATDN2
Tdark
Family: Enzyme
Novelty: 2.76923077
Score: 0.577
Data Source: STRINGDB
SHISAL1
Tdark
Novelty: 2.04878049
Score: 0.57
Data Source: STRINGDB
PRUNE1
Tchem
Novelty: 0.00162167
Score: 0.554
Data Source: STRINGDB
ACP7
Tdark
Family: Enzyme
Novelty: 0.06122449
Score: 0.545
Data Source: STRINGDB
VPS39
Tbio
Novelty: 0.03446657
Score: 0.501
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.80

PubMed score by year
PubTator Score  3.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer