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Tchem
AQP3
Aquaporin-3

Protein Summary
Description
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel functi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297991
  • ENSP00000297991
  • ENSG00000165272

Symbol
  • GIL
  • AQP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
small molecule perturbation
0.95
gene perturbation
0.81
biological term
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 613.84   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 613.84   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (59)
STX4
Tbio
Novelty:  0.00831588
Score:  0.927
Data Source:  STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
Score:  0.905
Data Source:  STRINGDB
EXOC4
Tbio
Novelty:  0.01636648
Score:  0.903
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.87
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.868
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.665
Data Source:  STRINGDB
AQP12B
Tdark
Novelty:  0.40546451
Score:  0.643
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.634
Data Source:  STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
Score:  0.631
Data Source:  STRINGDB
AVPR2
Tclin
Family:  GPCR
Novelty:  0.0009139
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
1
1
24.5
glucose measurement
1
1
1
6.1
1
1
0
1.1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
24.5
glucose measurement
1
6.1
0
1.1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 3
VGNC:4616
465045
Macaque
aquaporin 3 (Gill blood group)
702721
Mouse
MGI:1333777
11828
Rat
RGD:68428
65133
Dog
aquaporin 3
VGNC:51701
611792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 3
Macaque
aquaporin 3 (Gill blood group)
Mouse
Rat
Dog
aquaporin 3
Publication Statistics
PubMed Score 613.84
PubMed score by year
PubTator Score 291.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title