Protein Summary
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel functi ...more
- ENST00000297991
- ENSP00000297991
- ENSG00000165272
- GIL
- AQP-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 1 | ||
small molecule perturbation | 0.95 | ||
gene perturbation | 0.81 | ||
biological term | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 613.84 (req: < 5)
Gene RIFs: 127 (req: <= 3)
Antibodies: 322 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 613.84 (req: >= 5)
Gene RIFs: 127 (req: > 3)
Antibodies: 322 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (59)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Reactome | Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (6)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
albuminuria | 1 | 1 | 1 | 24.5 | |||||
glucose measurement | 1 | 1 | 1 | 6.1 | |||||
1 | 1 | 0 | 1.1 | 1.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
albuminuria | 1 | 24.5 | |||||
glucose measurement | 1 | 6.1 | |||||
0 | 1.1 | 1.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aquaporin 3 | VGNC:4616 | 465045 | |||||
Macaque | aquaporin 3 (Gill blood group) | 702721 | ||||||
Mouse | MGI:1333777 | 11828 | ||||||
Rat | RGD:68428 | 65133 | ||||||
Dog | aquaporin 3 | VGNC:51701 | 611792 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aquaporin 3 | |||||
Macaque | aquaporin 3 (Gill blood group) | |||||
Mouse | ||||||
Rat | ||||||
Dog | aquaporin 3 | |||||
Publication Statistics
PubMed Score 613.84
PubMed score by year
PubTator Score 291.37
PubTator score by year
Related Publications
Text Mined References (165)
GeneRif Annotations (127)
Items per page:
0 of 0
PMID | Year | Title |
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