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Tchem
AQP3
Aquaporin-3

Protein Classes
Protein Summary
Description
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel functi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297991
  • ENSP00000297991
  • ENSG00000165272

Symbol
  • GIL
  • AQP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
small molecule perturbation
0.95
gene perturbation
0.81
biological term
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.28   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.28   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
Audien
no chemical structure image available
Auphen
no chemical structure image available
Pathways (7)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (59)
1 – 10 of 59
STX4
Tbio
Novelty: 0.01072491
Score: 0.927
Data Source: STRINGDB
EXOC3
Tbio
Novelty: 0.01423005
Score: 0.905
Data Source: STRINGDB
EXOC4
Tbio
Novelty: 0.02000189
Score: 0.903
Data Source: STRINGDB
AQP12A
Tbio
Novelty: 0.0840303
Score: 0.87
Data Source: STRINGDB
AQP11
Tbio
Novelty: 0.02650569
Score: 0.868
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.0001163
Score: 0.665
Data Source: STRINGDB
AQP12B
Tdark
Novelty: 0.75471698
Score: 0.643
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.634
Data Source: STRINGDB
GK
Tbio
Family: Kinase
Novelty: 0.00835719
Score: 0.631
Data Source: STRINGDB
AVPR2
Tclin
Family: GPCR
Novelty: 0.00044183
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  465.28

PubMed score by year
PubTator Score  291.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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