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Tchem
RAPGEF4
Rap guanine nucleotide exchange factor 4

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397081
  • ENSP00000380271
  • ENSG00000091428
  • ENST00000397087
  • ENSP00000380276
  • ENST00000538974
  • ENSP00000440135
  • ENST00000540783
  • ENSP00000440250

Symbol
  • CGEF2
  • EPAC2
  • EPAC
  • CGEF2
  • EPAC2
  • EPAC 2
  • Nbla00496
  • CAMP-GEFII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
transcription factor perturbation
0.8
PubMedID
0.78
biological process
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
3
3
75.3
mathematical ability
3
2
3
71.2
gut microbiome measurement
1
1
2
46.2
intelligence
1
1
1
25.4
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
75.3
mathematical ability
3
71.2
gut microbiome measurement
2
46.2
intelligence
1
25.4
1
25.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 4
VGNC:2797
459744
Macaque
Rap guanine nucleotide exchange factor 4
698148
Mouse
MGI:1917723
56508
Dog
Rap guanine nucleotide exchange factor 4
VGNC:53103
488402
Horse
Rap guanine nucleotide exchange factor 4
VGNC:22182
100064121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 4
Macaque
Rap guanine nucleotide exchange factor 4
Mouse
Dog
Rap guanine nucleotide exchange factor 4
Horse
Rap guanine nucleotide exchange factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WZA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Reactome
Hemostasis
Reactome
Immune System
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Hemostasis
Immune System
Integration of energy metabolism
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (142)
1 – 10 of 142
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.991
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.99
Data Source: Reactome,STRINGDB
ABCC8
Tclin
Family: Transporter
Novelty: 0.00085572
Score: 0.983
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00510386
Score: 0.962
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.962
Data Source: STRINGDB
PCLO
Tbio
Novelty: 0.00918397
Score: 0.96
Data Source: STRINGDB
ADCY6
Tchem
Family: Enzyme
Novelty: 0.00528765
Score: 0.96
Data Source: STRINGDB
RIMS2
Tbio
Novelty: 0.02785894
Score: 0.958
Data Source: STRINGDB
KCNJ11
Tclin
Family: IC
Novelty: 0.00068183
Score: 0.955
Data Source: STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00351101
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  425.00

PubMed score by year
PubTator Score  66.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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