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Tbio
ROBO4
Roundabout homolog 4

Protein Summary
Description
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306534
  • ENSP00000304945
  • ENSG00000154133

Symbol
  • MRB
  • ECSM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.71
tissue sample
0.69
transcription factor perturbation
0.61
tissue
0.6


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.59   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.59   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921394
74144
Rat
RGD:6494870
100911068
Rat
RGD:727947
300518
Dog
roundabout guidance receptor 4
VGNC:45687
489306
Horse
roundabout guidance receptor 4
VGNC:22495
100072289
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Rat
Dog
roundabout guidance receptor 4
Horse
roundabout guidance receptor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WZ75-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (217)
Items per page:
1 – 5 of 217
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Robo4 and VEGF Signaling Pathways Crosstalk
WikiPathways
Robo4 and VEGF Signaling Pathways Crosstalk
WikiPathways
Robo4 and VEGF Signaling Pathways Crosstalk
WikiPathways
Nanoparticle triggered regulated necrosis
WikiPathways
Nanoparticle triggered regulated necrosis
Name
Explore in Pharos
Explore in Source
Robo4 and VEGF Signaling Pathways Crosstalk
Robo4 and VEGF Signaling Pathways Crosstalk
Robo4 and VEGF Signaling Pathways Crosstalk
Nanoparticle triggered regulated necrosis
Nanoparticle triggered regulated necrosis
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
SLIT2
Tbio
Novelty:  0.00710401
Score:  0.951
Data Source:  STRINGDB
SLIT3
Tbio
Novelty:  0.00465012
Score:  0.915
Data Source:  STRINGDB
SLIT1
Tbio
Novelty:  0.01255624
Score:  0.834
Data Source:  STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.705
Data Source:  STRINGDB
CLEC14A
Tbio
Novelty:  0.03231666
Score:  0.668
Data Source:  STRINGDB
CDH5
Tbio
Novelty:  0.00072649
Score:  0.659
Data Source:  STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
Score:  0.645
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.645
Data Source:  STRINGDB
TEK
Tclin
Family:  Kinase
Novelty:  0.00079268
Score:  0.627
Data Source:  STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.625
Data Source:  STRINGDB
Publication Statistics
PubMed Score  102.59

PubMed score by year
PubTator Score  58.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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