Tbio ROBO4 Roundabout homolog 4

Protein Summary

Description

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Uniprot Accession IDs

• Q8WZ75
• A8K154
• Q14DU7
• Q8TEG1
• Q96JV6
• Q9H718
• Q9NWJ8

Gene Name

• ROBO4

Ensembl ID

• ENST00000306534
• ENSP00000304945
• ENSG00000154133

Symbol

• MRB
• ECSM4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
PubMedID	0.71
tissue sample	0.69
transcription factor perturbation	0.61
tissue	0.6

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Roundabout Homolog 4

DTO Classes

Protein / Receptor / Roundabout Homolog 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.49   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.49   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0