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Tbio
RFFL
E3 ubiquitin-protein ligase rififylin

Protein Summary
Description
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315249
  • ENSP00000326170
  • ENSG00000092871
  • ENST00000394597
  • ENSP00000378096
  • ENST00000413582
  • ENSP00000408513
  • ENST00000415395
  • ENSP00000412322
  • ENST00000447669
  • ENSP00000389832
  • ENST00000584655
  • ENSP00000463035

Symbol
  • RNF189
  • RNF34L
  • CARP2
  • FRING
  • CARP-2
  • RNF189
  • RNF34L
  • RIFIFYLIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor binding site profile
0.85
transcription factor perturbation
0.84
biological process
0.81
molecular function
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
1
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
1
1
48.5
pulse pressure measurement
1
1
1
45.7
electrocardiography
1
1
17
40.7
TPE interval measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
48.5
pulse pressure measurement
1
45.7
electrocardiography
17
40.7
TPE interval measurement
1
21.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914588
67338
Rat
RGD:727916
282844
Dog
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
491144
Horse
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
100058179
Cow
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
530263
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Horse
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Cow
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WZ73-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (66)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Degradation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Degradation
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.999981591
p_ni:  0.000018407
p_wrong:  2e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
IQCE
Tdark
Novelty:  0.24800472
p_int:  0.999938609
p_ni:  0.000022439
p_wrong:  0.000038953
Score:  0.54
Data Source:  BioPlex,STRINGDB
PRKD2
Tchem
Family:  Kinase
Novelty:  0.03143723
p_int:  0.998943069
p_ni:  0.001056902
p_wrong:  2.9e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
EFCAB7
Tdark
Novelty:  0.36952617
p_int:  0.928757719
p_ni:  0.000497005
p_wrong:  0.070745276
Score:  0.319
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.943
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.926
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.905
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.903
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.9
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.15

PubMed score by year
PubTator Score  5.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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