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Tbio
ARAP2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Protein Summary
Description
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303965
  • ENSP00000302895
  • ENSG00000047365

Symbol
  • CENTD1
  • KIAA0580
  • PARX
  • CENTD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.84
virus perturbation
0.76
microRNA
0.69
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
5.7
31.6
influenza A (H1N1)
2
1
0
3.5
28
metabolic syndrome
1
1
1
22.8
diastolic blood pressure
1
1
1
21.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
5.7
31.6
influenza A (H1N1)
0
3.5
28
metabolic syndrome
1
22.8
diastolic blood pressure
1
21.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
VGNC:2947
461158
Macaque
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
702115
Mouse
MGI:2684416
212285
Dog
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
VGNC:38026
488840
Horse
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
VGNC:15440
100065339
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Macaque
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Mouse
Dog
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Horse
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WZ64-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Protein-Protein Interactions (70)
1 – 10 of 70
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.952
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.934
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.933
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.929
Data Source: STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.929
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.926
Data Source: STRINGDB
RHOV
Tbio
Family: Enzyme
Novelty: 0.02138482
Score: 0.924
Data Source: STRINGDB
RHOBTB1
Tbio
Novelty: 0.02152609
Score: 0.922
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.922
Data Source: STRINGDB
RHOH
Tbio
Family: Enzyme
Novelty: 0.00882842
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.86

PubMed score by year
PubTator Score  5.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer