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Tbio
RSPH1
Radial spoke head 1 homolog

Protein Summary
Description
May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes. This gene encodes a male meiotic metaphase chromosome-associated acidic protein. This gene is expressed in tissues with motile cilia or flagella, including the trachea, lungs, airway brushings, and testes. Mutations in this gene result in primary ciliary dyskinesia-24. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291536
  • ENSP00000291536
  • ENSG00000160188
  • ENST00000398352
  • ENSP00000381395

Symbol
  • TSA2
  • TSGA2
  • CT79
  • TSA2
  • RSP44
  • TSGA2
  • RSPH10A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor
0.6
cell type or tissue
0.58
transcription factor binding site profile
0.58
tissue sample
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
89.7
2
2
0
1.2
76.7
1
2
0
1.2
66.6
eosinophil count
2
1
2
64.9
lymphocyte count
2
1
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
89.7
0
1.2
76.7
0
1.2
66.6
eosinophil count
2
64.9
lymphocyte count
2
54.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 1 homolog
VGNC:7199
474127
Macaque
radial spoke head 1 homolog
714394
Mouse
MGI:1194909
22092
Rat
RGD:1307712
361818
Dog
radial spoke head 1 homolog
VGNC:45777
478420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 1 homolog
Macaque
radial spoke head 1 homolog
Mouse
Rat
Dog
radial spoke head 1 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WYR4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (96)
1 – 10 of 96
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999668641
p_ni:  0.000330565
p_wrong:  7.95e-7
Score:  0.599
Data Source:  BioPlex,STRINGDB
RSPH3
Tdark
Novelty:  0.04470453
Score:  0.825
Data Source:  STRINGDB
RSPH9
Tbio
Novelty:  0.08651313
Score:  0.806
Data Source:  STRINGDB
RSPH4A
Tbio
Novelty:  0.07992083
Score:  0.799
Data Source:  STRINGDB
LY6E
Tbio
Novelty:  0.00758512
Score:  0.708
Data Source:  STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
Score:  0.691
Data Source:  STRINGDB
DNAH5
Tbio
Novelty:  0.01579144
Score:  0.685
Data Source:  STRINGDB
CCDC114
Tbio
Novelty:  0.12534741
Score:  0.68
Data Source:  STRINGDB
DRC1
Tbio
Novelty:  0.29125683
Score:  0.677
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.675
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.83

PubMed score by year
PubTator Score  13.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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