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Tbio
CHCHD10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

Protein Summary
Description
May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000484558
  • ENSP00000418428
  • ENSG00000250479
  • ENST00000629095
  • ENSP00000487006
  • ENSG00000273607

Symbol
  • C22orf16
  • IMMD
  • SMAJ
  • MIX17A
  • FTDALS2
  • N27C7-4
  • C22orf16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
small molecule perturbation
0.98
cell type or tissue
0.74
biological process
0.7
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
BNC2
Tbio
Family:  TF
Novelty:  0.0181682
p_int:  0.999999992
p_wrong:  8e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.999999786
p_ni:  2.13e-7
Data Source:  BioPlex
RBM26
Tdark
Novelty:  0.26601554
p_int:  0.999999051
p_ni:  9.49e-7
Data Source:  BioPlex
RBM27
Tdark
Novelty:  0.04875536
p_int:  0.999992115
p_ni:  0.000007885
Data Source:  BioPlex
CHCHD2P9
Tdark
p_int:  0.999977397
p_ni:  0.000022603
Data Source:  BioPlex
BAG1
Tbio
Novelty:  0.00285515
p_int:  0.999823879
p_ni:  0.00017611
p_wrong:  1e-8
Data Source:  BioPlex
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.999810582
p_ni:  0.000189417
Score:  0.193
Data Source:  BioPlex,STRINGDB
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
p_int:  0.999759755
p_ni:  0.000240148
p_wrong:  9.7e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
p_int:  0.999643365
p_ni:  0.000355607
p_wrong:  0.000001028
Data Source:  BioPlex
PRRC2A
Tbio
Novelty:  0.01493149
p_int:  0.999640317
p_ni:  0.000359682
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
1
1
82.8
serum IgG glycosylation measurement
1
1
1
82.8
serum non-albumin protein measurement
1
2
2
76.7
serum non-albumin protein measurement
1
2
2
76.7
2
1
0
1.3
67.9
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
82.8
serum IgG glycosylation measurement
1
82.8
serum non-albumin protein measurement
2
76.7
serum non-albumin protein measurement
2
76.7
0
1.3
67.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2143558
103172
Rat
RGD:1359417
361824
Dog
coiled-coil-helix-coiled-coil-helix domain containing 10
VGNC:39194
477560
Cow
coiled-coil-helix-coiled-coil-helix domain containing 10
VGNC:27271
615846
Pig
coiled-coil-helix-coiled-coil-helix domain containing 10
100152325
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
coiled-coil-helix-coiled-coil-helix domain containing 10
Cow
coiled-coil-helix-coiled-coil-helix domain containing 10
Pig
coiled-coil-helix-coiled-coil-helix domain containing 10
Publication Statistics
PubMed Score 69.93
PubMed score by year
PubTator Score 43.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title