CHCHD10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
Protein Summary
May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]
- ENST00000484558
- ENSP00000418428
- ENSG00000250479
- ENST00000629095
- ENSP00000487006
- ENSG00000273607
- C22orf16
- IMMD
- SMAJ
- MIX17A
- FTDALS2
- N27C7-4
- C22orf16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
small molecule perturbation | 0.98 | ||
cell type or tissue | 0.74 | ||
biological process | 0.7 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.93 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.93 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (103)
BNC2
Family: TF
Novelty: 0.0181682
p_int: 0.999999992
p_wrong: 8e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
RBM23
Novelty: 0.03769792
p_int: 0.999810582
p_ni: 0.000189417
Score: 0.193
Data Source: BioPlex,STRINGDB
ZFP91
Family: TF
Novelty: 0.06937322
p_int: 0.999759755
p_ni: 0.000240148
p_wrong: 9.7e-8
Score: 0.222
Data Source: BioPlex,STRINGDB
PHF10
Family: Epigenetic
Novelty: 0.05941323
p_int: 0.999643365
p_ni: 0.000355607
p_wrong: 0.000001028
Data Source: BioPlex
PRRC2A
Novelty: 0.01493149
p_int: 0.999640317
p_ni: 0.000359682
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Mitochondrial protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Mitochondrial protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Components (4)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 1 | 1 | 82.8 | ||||||
serum IgG glycosylation measurement | 1 | 1 | 1 | 82.8 | ||||||
serum non-albumin protein measurement | 1 | 2 | 2 | 76.7 | ||||||
serum non-albumin protein measurement | 1 | 2 | 2 | 76.7 | ||||||
2 | 1 | 0 | 1.3 | 67.9 | ||||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 82.8 | |||||
serum IgG glycosylation measurement | 1 | 82.8 | |||||
serum non-albumin protein measurement | 2 | 76.7 | |||||
serum non-albumin protein measurement | 2 | 76.7 | |||||
0 | 1.3 | 67.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2143558 | 103172 | ||||||
Rat | RGD:1359417 | 361824 | ||||||
Dog | coiled-coil-helix-coiled-coil-helix domain containing 10 | VGNC:39194 | 477560 | |||||
Cow | coiled-coil-helix-coiled-coil-helix domain containing 10 | VGNC:27271 | 615846 | |||||
Pig | coiled-coil-helix-coiled-coil-helix domain containing 10 | 100152325 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | coiled-coil-helix-coiled-coil-helix domain containing 10 | |||||
Cow | coiled-coil-helix-coiled-coil-helix domain containing 10 | |||||
Pig | coiled-coil-helix-coiled-coil-helix domain containing 10 | |||||
Publication Statistics
PubMed Score 69.93
PubMed score by year
PubTator Score 43.11
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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