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Tbio
AHCTF1
Protein ELYS

Protein Summary
Description
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326225
  • ENSP00000355465
  • ENSG00000153207
  • ENST00000366508
  • ENSP00000355464
  • ENST00000648844
  • ENSP00000497061

Symbol
  • ELYS
  • TMBS62
  • ELYS
  • MST108
  • TMBS62
  • MSTP108
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.91
histone modification site profile
0.88
ligand (protein) perturbation
0.83
disease perturbation
0.79
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.829186742
p_ni:  0.170813257
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.760977217
p_ni:  0.239022783
Score:  0.163
Data Source:  BioPlex,STRINGDB
NUP160
Tbio
Novelty:  0.03667026
Score:  0.995
Data Source:  STRINGDB
NUP133
Tbio
Novelty:  0.02115225
Score:  0.994
Data Source:  STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.992
Data Source:  STRINGDB
NUP43
Tbio
Novelty:  0.11571309
Score:  0.987
Data Source:  STRINGDB
NUP37
Tbio
Novelty:  0.1270421
Score:  0.986
Data Source:  STRINGDB
NUP85
Tbio
Novelty:  0.02350514
Score:  0.985
Data Source:  STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
Score:  0.984
Data Source:  STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
AT-hook containing transcription factor 1
702705
Mouse
MGI:1915033
226747
Rat
RGD:1561291
360886
Dog
AT-hook containing transcription factor 1
VGNC:37723
480106
Horse
AT-hook containing transcription factor 1
VGNC:15177
100054592
Species
Name
OMA
EggNOG
Inparanoid
Macaque
AT-hook containing transcription factor 1
Mouse
Rat
Dog
AT-hook containing transcription factor 1
Horse
AT-hook containing transcription factor 1
Publication Statistics
PubMed Score 41.57
PubMed score by year
PubTator Score 12.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title