Protein Summary
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
- ENST00000326225
- ENSP00000355465
- ENSG00000153207
- ENST00000366508
- ENSP00000355464
- ENST00000648844
- ENSP00000497061
- ELYS
- TMBS62
- ELYS
- MST108
- TMBS62
- MSTP108
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.91 | ||
histone modification site profile | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.32 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.32 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0