Tbio AHCTF1 Protein ELYS

Protein Summary

Description

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Uniprot Accession IDs

• Q8WYP5
• A6NGM0
• A8MSG9
• A8MZ86
• Q7Z4E3
• Q8IZA4
• Q96EH9
• Q9Y4Q6

Gene Name

• AHCTF1

Ensembl ID

• ENST00000326225
• ENSP00000355465
• ENSG00000153207
• ENST00000366508
• ENSP00000355464
• ENST00000648844
• ENSP00000497061

Symbol

• ELYS
• TMBS62
• ELYS
• MST108
• TMBS62
• MSTP108

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.91
histone modification site profile	0.88
ligand (protein) perturbation	0.83
disease perturbation	0.79
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

IL13RA2

Tbio

Novelty:  0.03465642

p_int:  0.829186742

p_ni:  0.170813257

p_wrong:  1e-9

Score:  0.183

Data Source:  BioPlex,STRINGDB

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.760977217

p_ni:  0.239022783

Score:  0.163

Data Source:  BioPlex,STRINGDB

NUP160

Tbio

Novelty:  0.03667026

Score:  0.995

Data Source:  STRINGDB

NUP133

Tbio

Novelty:  0.02115225

Score:  0.994

Data Source:  STRINGDB

NUP107

Tbio

Novelty:  0.01994155

Score:  0.992

Data Source:  STRINGDB

NUP43

Tbio

Novelty:  0.11571309

Score:  0.987

Data Source:  STRINGDB

NUP37

Tbio

Novelty:  0.1270421

Score:  0.986

Data Source:  STRINGDB

NUP85

Tbio

Novelty:  0.02350514

Score:  0.985

Data Source:  STRINGDB

RANBP2

Tbio

Family:  Enzyme

Novelty:  0.00484823

Score:  0.984

Data Source:  STRINGDB

SEC13

Tbio

Novelty:  0.00709413

Score:  0.983

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (16)

WikiPathways (6)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (8)

Processes (6)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		70.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		70.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
Cytoplasm
DNA-binding
Kinetochore
mRNA transport

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	AT-hook containing transcription factor 1		702705
Mouse	AT hook containing transcription factor 1	MGI:1915033	226747
Rat	AT hook containing transcription factor 1	RGD:1561291	360886
Dog	AT-hook containing transcription factor 1	VGNC:37723	480106
Horse	AT-hook containing transcription factor 1	VGNC:15177	100054592

Species	Name	OMA	EggNOG	Inparanoid
Macaque	AT-hook containing transcription factor 1
Mouse	AT hook containing transcription factor 1
Rat	AT hook containing transcription factor 1
Dog	AT-hook containing transcription factor 1
Horse	AT-hook containing transcription factor 1

Publication Statistics

PubMed Score 41.57

PubMed score by year

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PubTator Score 12.84

PubTator score by year

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Related Publications

Text Mined References (13)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title