You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATG4A
Cysteine protease ATG4A

Protein Summary
Description
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345734
  • ENSP00000298131
  • ENSG00000101844
  • ENST00000372232
  • ENSP00000361306

Symbol
  • APG4A
  • AUTL2
  • APG4A
  • AUTL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
interacting protein
0.62
tissue sample
0.62
biological process
0.6
virus perturbation
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4A cysteine peptidase
VGNC:7792
473725
Macaque
autophagy related 4A cysteine peptidase
703367
Mouse
MGI:2147903
666468
Dog
autophagy related 4A cysteine peptidase
VGNC:38223
481015
Horse
autophagy related 4A cysteine peptidase
VGNC:15623
100060165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4A cysteine peptidase
Macaque
autophagy related 4A cysteine peptidase
Mouse
Dog
autophagy related 4A cysteine peptidase
Horse
autophagy related 4A cysteine peptidase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WYN0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Protein-Protein Interactions (90)
1 – 10 of 90
LCN15
Tdark
Novelty: 0.54935158
p_int: 0.99791524
p_ni: 0.00175578
p_wrong: 0.00032898
Score: 0.534
Data Source: BioPlex,STRINGDB
BCAS4
Tbio
Novelty: 0.11759439
p_int: 0.99791524
p_ni: 0.00175578
p_wrong: 0.00032898
Score: 0.219
Data Source: BioPlex,STRINGDB
C1orf220
Tdark
p_int: 0.99791524
p_ni: 0.00175578
p_wrong: 0.00032898
Data Source: BioPlex
HSPB6
Tbio
Novelty: 0.00317712
p_int: 0.982614283
p_ni: 0.017249362
p_wrong: 0.000136355
Score: 0.346
Data Source: BioPlex,STRINGDB
BOD1
Tbio
Novelty: 0.06404805
p_int: 0.982614283
p_ni: 0.017249362
p_wrong: 0.000136355
Score: 0.209
Data Source: BioPlex,STRINGDB
GABARAPL2
Tbio
Novelty: 0.0022546
Score: 0.991
Data Source: STRINGDB
GABARAPL1
Tbio
Novelty: 0.00212657
Score: 0.99
Data Source: STRINGDB
MAP1LC3A
Tbio
Novelty: 0.00301583
Score: 0.986
Data Source: STRINGDB
GABARAP
Tbio
Novelty: 0.00444901
Score: 0.986
Data Source: STRINGDB
MAP1LC3B
Tbio
Novelty: 0.00101276
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.35

PubMed score by year
PubTator Score  10.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer