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Tbio
ACOT12
Acyl-coenzyme A thioesterase 12

Protein Summary
Description
Hydrolyzes acetyl-CoA to acetate and CoA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307624
  • ENSP00000303246
  • ENSG00000172497
  • ENST00000513751
  • ENSP00000421628

Symbol
  • CACH
  • CACH1
  • STARD15
  • Cach
  • THEAL
  • CACH-1
  • STARD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.63
protein domain
0.58
virus perturbation
0.5
cell line
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 12
VGNC:3888
461769
Macaque
acyl-CoA thioesterase 12
711665
Mouse
MGI:1921406
74156
Rat
RGD:619752
170570
Dog
acyl-CoA thioesterase 12
VGNC:37517
488925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 12
Macaque
acyl-CoA thioesterase 12
Mouse
Rat
Dog
acyl-CoA thioesterase 12
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WYK0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
ZBTB8A
Tdark
Family: TF
Novelty: 0.65458116
p_int: 0.999998517
p_ni: 1.4e-8
p_wrong: 0.000001469
Score: 0.379
Data Source: BioPlex,STRINGDB
ACOT11
Tbio
Family: Enzyme
Novelty: 0.0400726
p_int: 0.999996072
p_ni: 2.7e-8
p_wrong: 0.000003901
Score: 0.304
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.992511582
p_ni: 0.007488418
Score: 0.186
Data Source: BioPlex,STRINGDB
TLR5
Tbio
Novelty: 0.00110868
p_int: 0.966722071
p_ni: 0.000002559
p_wrong: 0.03327537
Score: 0.219
Data Source: BioPlex,STRINGDB
SPAG9
Tbio
Family: Enzyme
Novelty: 0.00527315
p_int: 0.932728006
p_ni: 0.067271994
Score: 0.183
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.906950569
p_ni: 0.093049431
Score: 0.181
Data Source: BioPlex,STRINGDB
ACSS2
Tbio
Family: Enzyme
Novelty: 0.00448879
Score: 0.938
Data Source: STRINGDB
ACAT2
Tchem
Family: Enzyme
Novelty: 0.01464168
Score: 0.914
Data Source: STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.00908928
Score: 0.913
Data Source: STRINGDB
ACACB
Tchem
Family: Enzyme
Novelty: 0.00462116
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.42

PubMed score by year
PubTator Score  13.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer