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Tbio
ING5
Inhibitor of growth protein 5

Protein Summary
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313552
  • ENSP00000322142
  • ENSG00000168395
  • ENST00000406941
  • ENSP00000385937

Symbol
  • p28ING5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.89
biological process
0.78
transcription factor binding site profile
0.73
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.1   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.1   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999999967
p_ni:  3.1e-8
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KAT7
Tbio
Family:  TF; Epigenetic
Novelty:  0.01783137
p_int:  0.999993828
p_ni:  0.0000058
p_wrong:  3.71e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KAT6A
Tchem
Family:  Epigenetic
Novelty:  0.00478771
Score:  0.99
Data Source:  Reactome,STRINGDB
KAT6B
Tchem
Family:  Epigenetic
Novelty:  0.00361345
Score:  0.987
Data Source:  Reactome,STRINGDB
BRPF1
Tchem
Family:  Epigenetic
Novelty:  0.02524021
Score:  0.976
Data Source:  Reactome,STRINGDB
BRPF3
Tchem
Family:  Epigenetic
Novelty:  0.14559787
Score:  0.974
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.974
Data Source:  Reactome,STRINGDB
JADE1
Tbio
Family:  Epigenetic
Novelty:  0.06758769
Score:  0.972
Data Source:  Reactome,STRINGDB
BRD1
Tchem
Family:  Epigenetic
Novelty:  0.00412359
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
5
5
97.9
6
2
2
1.1
90.7
eosinophil count
3
1
3
86.9
blood protein measurement
1
1
1
86.5
10
1
0
1.1
86.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
5
97.9
2
1.1
90.7
eosinophil count
3
86.9
blood protein measurement
1
86.5
0
1.1
86.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 5
VGNC:1975
460085
Macaque
inhibitor of growth family member 5
701901
Mouse
MGI:1922816
66262
Rat
RGD:1307908
363292
Dog
inhibitor of growth family member 5
VGNC:42019
607562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 5
Macaque
inhibitor of growth family member 5
Mouse
Rat
Dog
inhibitor of growth family member 5
Publication Statistics
PubMed Score 41.10
PubMed score by year
PubTator Score 26.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title