Tbio ING5 Inhibitor of growth protein 5

Protein Summary

Description

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q8WYH8
• A8K1P3
• Q53NU6
• Q57Z54
• Q9BS30

Gene Name

• ING5

Ensembl ID

• ENST00000313552
• ENSP00000322142
• ENSG00000168395
• ENST00000406941
• ENSP00000385937

Symbol

• p28ING5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.89
biological process	0.78
transcription factor binding site profile	0.73
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Inhibitor Of Growth Protein 5

Protein / Transcription Factor / Transcription Cofactor / Inhibitor Of Growth Protein 5

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Inhibitor Of Growth Protein 5

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Inhibitor Of Growth Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.95   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.95   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0