Tbio CTNNBL1 Beta-catenin-like protein 1

Protein Summary

Description

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q8WYA6
• B4DE16
• Q0VAL9
• Q0VAM0
• Q53HI8
• Q5JWZ2
• Q5JWZ3
• Q5JWZ7
• Q5JWZ8
• Q8N454
• Q8NCL2
• Q8TBD6
• Q96KD2
• Q9H7A5
• Q9NQF9
• Q9NTX0
• Q9Y3M7

Gene Name

• CTNNBL1

Ensembl ID

• ENST00000361383
• ENSP00000355050
• ENSG00000132792
• ENST00000373469
• ENSP00000362568
• ENST00000373473
• ENSP00000362572
• ENST00000405275
• ENSP00000384355
• ENST00000628103
• ENSP00000487198

Symbol

• C20orf33
• NAP
• P14L
• PP8304
• C20orf33
• dJ633O20.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
cell type or tissue	0.77
histone modification site profile	0.74
transcription factor perturbation	0.74
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.09   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.09   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0