Tbio IFT81 Intraflagellar transport protein 81 homolog

Protein Summary

Description

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822). The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q8WYA0
• Q2YDY1
• Q8NB51
• Q9BSV2
• Q9UNY8

Gene Name

• IFT81

Ensembl ID

• ENST00000242591
• ENSP00000242591
• ENSG00000122970
• ENST00000361948
• ENSP00000355372
• ENST00000552912
• ENSP00000449718

Symbol

• CDV1
• DV1
• CDV1
• CDV-1
• CDV1R
• CDV-1R
• SRTD19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.82
transcription factor perturbation	0.8
cell line	0.63
transcription factor	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.56   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.56   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0